Cloned (Comment) | Organism |
---|---|
coexpression with NADPH-cytochrome P450 reductase in Sf9 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
G312R | natural genetic variant, almost complete loss of enzymatic activity. Loss of CO binding to the heme, molecular modelling predicts a spatial hindrance between heme and the bulky side chain of the R312 residue in G312R | Homo sapiens |
additional information | identification of 12 genetic variations from 93 Korean subjects | Homo sapiens |
P351L | natural genetic variant, activity similar to wild-type | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
danazol | - |
Homo sapiens | |
hydroxyebastine | - |
Homo sapiens | |
telmisartan | - |
Homo sapiens | |
terfenadone | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P51589 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
albendazole + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 4'-hydroxyalbendazole + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
astemizole + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | hydroxyastemizole + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
ebastine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | hydroxyebastine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
terfenadine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | terfenadine alcohol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP2J2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00015 | - |
substrate astemizole, liver microsome, pH 7.4, 37°C | Homo sapiens | terfenadone | |
0.00031 | - |
substrate albendazole, liver microsome, pH 7.4, 37°C | Homo sapiens | terfenadone | |
0.00195 | - |
substrate ebastine, liver microsome, pH 7.4, 37°C | Homo sapiens | danazol | |
0.0021 | - |
substrate terfenadine, liver microsome, pH 7.4, 37°C | Homo sapiens | terfenadone | |
0.00214 | - |
substrate terfenadine, liver microsome, pH 7.4, 37°C | Homo sapiens | danazol | |
0.004 | - |
substrate terfenadine, liver microsome, pH 7.4, 37°C | Homo sapiens | hydroxyebastine | |
0.00427 | - |
substrate ebastine, liver microsome, pH 7.4, 37°C | Homo sapiens | terfenadone | |
0.00928 | - |
substrate astemizole, liver microsome, pH 7.4, 37°C | Homo sapiens | hydroxyebastine | |
0.0111 | - |
substrate albendazole, liver microsome, pH 7.4, 37°C | Homo sapiens | hydroxyebastine | |
0.0138 | - |
substrate albendazole, liver microsome, pH 7.4, 37°C | Homo sapiens | danazol | |
0.0183 | - |
substrate astemizole, liver microsome, pH 7.4, 37°C | Homo sapiens | danazol | |
0.0238 | - |
substrate terfenadine, liver microsome, pH 7.4, 37°C | Homo sapiens | telmisartan | |
0.0472 | - |
substrate albendazole, liver microsome, pH 7.4, 37°C | Homo sapiens | telmisartan |