BRENDA - Enzyme Database show
show all sequences of 1.14.14.79

Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism

Fer, M.; Corcos, L.; Dreano, Y.; Plee-Gautier, E.; Salaün, J.; Berthou, F.; Amet, Y.; J. Lipid Res. 49, 2379-2389 (2008)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
docosahexaenoic acid
10 microM, 70% inhibition of arachidonic acid metabolism
Homo sapiens
eicosapentaenoic acid
10 microM, 56% inhibition of arachidonic acid metabolism
Homo sapiens
eicosatrienoic acid
10 microM, 32% inhibition of arachidonic acid metabolism
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q08477
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
docosahexaenoic acid + [reduced NADPH-hemoprotein reductase] + O2
-
704996
Homo sapiens
22-hydroxydocosahexaenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
eicosapentaenoic acid + NADPH + H+ + O2
-
704996
Homo sapiens
20-hydroxyeicosapentaenoic acid + NADP+ + H2O
-
-
-
?
eicosatrienoic acid + [reduced NADPH-hemoprotein reductase] + O2
-
704996
Homo sapiens
20-hydroxyeicosatrienoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
docosahexaenoic acid
10 microM, 70% inhibition of arachidonic acid metabolism
Homo sapiens
eicosapentaenoic acid
10 microM, 56% inhibition of arachidonic acid metabolism
Homo sapiens
eicosatrienoic acid
10 microM, 32% inhibition of arachidonic acid metabolism
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
docosahexaenoic acid + [reduced NADPH-hemoprotein reductase] + O2
-
704996
Homo sapiens
22-hydroxydocosahexaenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
eicosapentaenoic acid + NADPH + H+ + O2
-
704996
Homo sapiens
20-hydroxyeicosapentaenoic acid + NADP+ + H2O
-
-
-
?
eicosatrienoic acid + [reduced NADPH-hemoprotein reductase] + O2
-
704996
Homo sapiens
20-hydroxyeicosatrienoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Other publictions for EC 1.14.14.79
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
728344
Nakano
CYP4V2 in Bietti’s crystalli ...
Homo sapiens
Mol. Pharmacol.
82
679-686
2012
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-
1
-
1
-
-
-
2
-
2
1
-
2
-
-
1
-
-
15
-
-
3
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
2
-
2
1
-
-
-
1
-
15
-
-
3
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
729628
Madec
CYP4F3B expression is associat ...
Homo sapiens
Drug Metab. Dispos.
39
1987-1996
2011
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1
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2
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1
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2
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1
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-
-
-
-
1
-
-
1
-
-
704996
Fer
Cytochromes P450 from family 4 ...
Homo sapiens
J. Lipid Res.
49
2379-2389
2008
-
-
-
-
-
-
3
-
-
-
-
-
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1
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3
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3
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3
-
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-
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-
730854
Harmon
Oxygenation of omega-3 fatty a ...
Homo sapiens
Prostaglandins Leukot. Essent. Fatty Acids
75
169-177
2006
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-
-
-
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3
-
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1
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3
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3
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3
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