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show all sequences of 1.14.14.80

Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases

Hoch, U.; Zhang, Z.; Kroetz, D.L.; Ortiz de Montellano, P.R.; Arch. Biochem. Biophys. 373, 63-71 (2000)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression in Escherichia coli
Homo sapiens
expression in Escherichia coli; expression in Escherichia coli; expression in Escherichia coli; expression in Escherichia coli
Rattus norvegicus
Engineering
Amino acid exchange
Commentary
Organism
additional information
construction of two complementary chimera between isoforms CYP4A2-CYP4A3 fused at residue 119 (CYP4A2) and 122 (CYP4A3). The chimera in which the first 119 amino acids are from CYP4A2 indicates that the first 120 amino acids control the substrate specificity. The chimera in which the first 122 amino acids are from CYP4A3 is inactive due to a defect in electron transfer to the heme group; construction of two complementary chimera between isoforms CYP4A2-CYP4A3 fused at residue 119 (CYP4A2) and 122 (CYP4A3). The chimera in which the first 119 amino acids are from CYP4A2 indicates that the first 120 amino acids control the substrate specificity. The chimera in which the first 122 amino acids are from CYP4A3 is inactive due to a defect in electron transfer to the heme group
Rattus norvegicus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.003
-
arachidonic acid
pH 7.4, 37C
Rattus norvegicus
0.004
-
myristic acid
pH 7.4, 37C
Rattus norvegicus
0.01
-
arachidonic acid
pH 7.4, 37C
Homo sapiens
0.013
-
myristic acid
pH 7.4, 37C
Rattus norvegicus
0.018
-
oleic acid
pH 7.4, 37C
Rattus norvegicus
0.019
-
arachidonic acid
pH 7.4, 37C
Rattus norvegicus
0.022
-
lauric acid
pH 7.4, 37C
Homo sapiens
0.03
-
lauric acid
pH 7.4, 37C; pH 7.4, 37C
Rattus norvegicus
0.046
-
myristic acid
pH 7.4, 37C
Rattus norvegicus
0.064
-
oleic acid
pH 7.4, 37C
Rattus norvegicus
0.07
-
myristic acid
pH 7.4, 37C
Homo sapiens
0.08
-
lauric acid
pH 7.4, 37C
Rattus norvegicus
0.136
-
oleic acid
pH 7.4, 37C
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q02928
-
-
Rattus norvegicus
P08516
-
-
Rattus norvegicus
P20816
-
-
Rattus norvegicus
P20817
-
-
Rattus norvegicus
P24464
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
kidney
-
Rattus norvegicus
-
kidney
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
-
285382
Homo sapiens
20-hydroxyarachidonic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
-
285382
Rattus norvegicus
20-hydroxyarachidonic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 2.4:1
285382
Rattus norvegicus
20-hydroxyarachidonic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 2:1
285382
Rattus norvegicus
20-hydroxyarachidonic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 6:1
285382
Rattus norvegicus
20-hydroxyarachidonic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lauric acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 2.5:1
285382
Homo sapiens
12-hydroxylauric acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lauric acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 2.5:1
285382
Rattus norvegicus
12-hydroxylauric acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lauric acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 3:1
285382
Rattus norvegicus
12-hydroxylauric acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lauric acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 40:1
285382
Rattus norvegicus
12-hydroxylauric acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lauric acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 6:1
285382
Rattus norvegicus
12-hydroxylauric acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
myristic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 1.2:1
285382
Rattus norvegicus
14-hydroxymyristic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
myristic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 1.6:1
285382
Homo sapiens
14-hydroxymyristic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
myristic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 1.6:1
285382
Rattus norvegicus
14-hydroxymyristic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
myristic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 3:1
285382
Rattus norvegicus
14-hydroxymyristic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
oleic acid + [reduced NADPH-hemoprotein reductase] + O2
-
285382
Homo sapiens
18-hydroxyoleic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
oleic acid + [reduced NADPH-hemoprotein reductase] + O2
-
285382
Rattus norvegicus
18-hydroxyoleic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
palmitic acid + [reduced NADPH-hemoprotein reductase] + O2
-
285382
Rattus norvegicus
16-hydroxypalmitic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
palmitic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 1.6:1
285382
Homo sapiens
16-hydroxypalmitic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
palmitic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 1.6:1
285382
Rattus norvegicus
16-hydroxypalmitic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
palmitic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 1:1
285382
Rattus norvegicus
16-hydroxypalmitic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.01
-
arachidonic acid
pH 7.4, 37C
Homo sapiens
0.01
-
oleic acid
pH 7.4, 37C
Homo sapiens
0.01
-
oleic acid
pH 7.4, 37C; pH 7.4, 37C
Rattus norvegicus
0.02
-
arachidonic acid
pH 7.4, 37C
Rattus norvegicus
0.02
-
oleic acid
pH 7.4, 37C; pH 7.4, 37C
Rattus norvegicus
0.03
-
arachidonic acid
pH 7.4, 37C; pH 7.4, 37C
Rattus norvegicus
0.03
-
palmitic acid
pH 7.4, 37C
Rattus norvegicus
0.1
-
arachidonic acid
pH 7.4, 37C
Rattus norvegicus
0.1
-
myristic acid
pH 7.4, 37C
Rattus norvegicus
0.1
-
palmitic acid
pH 7.4, 37C
Rattus norvegicus
0.17
-
palmitic acid
pH 7.4, 37C
Homo sapiens
0.58
-
lauric acid
pH 7.4, 37C
Rattus norvegicus
0.67
-
myristic acid
pH 7.4, 37C
Rattus norvegicus
0.7
-
lauric acid
pH 7.4, 37C
Homo sapiens
0.83
-
myristic acid
pH 7.4, 37C
Homo sapiens
1
-
palmitic acid
pH 7.4, 37C
Rattus norvegicus
1.17
-
myristic acid
pH 7.4, 37C
Rattus norvegicus
1.22
-
lauric acid
pH 7.4, 37C
Rattus norvegicus
3.8
-
lauric acid
pH 7.4, 37C
Rattus norvegicus
3.8
-
myristic acid
pH 7.4, 37C
Rattus norvegicus
10.8
-
lauric acid
pH 7.4, 37C
Rattus norvegicus
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Escherichia coli
Homo sapiens
expression in Escherichia coli
Rattus norvegicus
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
construction of two complementary chimera between isoforms CYP4A2-CYP4A3 fused at residue 119 (CYP4A2) and 122 (CYP4A3). The chimera in which the first 119 amino acids are from CYP4A2 indicates that the first 120 amino acids control the substrate specificity. The chimera in which the first 122 amino acids are from CYP4A3 is inactive due to a defect in electron transfer to the heme group
Rattus norvegicus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.003
-
arachidonic acid
pH 7.4, 37C
Rattus norvegicus
0.004
-
myristic acid
pH 7.4, 37C
Rattus norvegicus
0.01
-
arachidonic acid
pH 7.4, 37C
Homo sapiens
0.013
-
myristic acid
pH 7.4, 37C
Rattus norvegicus
0.018
-
oleic acid
pH 7.4, 37C
Rattus norvegicus
0.019
-
arachidonic acid
pH 7.4, 37C
Rattus norvegicus
0.022
-
lauric acid
pH 7.4, 37C
Homo sapiens
0.03
-
lauric acid
pH 7.4, 37C
Rattus norvegicus
0.046
-
myristic acid
pH 7.4, 37C
Rattus norvegicus
0.064
-
oleic acid
pH 7.4, 37C
Rattus norvegicus
0.07
-
myristic acid
pH 7.4, 37C
Homo sapiens
0.08
-
lauric acid
pH 7.4, 37C
Rattus norvegicus
0.136
-
oleic acid
pH 7.4, 37C
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
kidney
-
Rattus norvegicus
-
kidney
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
-
285382
Homo sapiens
20-hydroxyarachidonic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
-
285382
Rattus norvegicus
20-hydroxyarachidonic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 2.4:1
285382
Rattus norvegicus
20-hydroxyarachidonic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 2:1
285382
Rattus norvegicus
20-hydroxyarachidonic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 6:1
285382
Rattus norvegicus
20-hydroxyarachidonic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lauric acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 2.5:1
285382
Homo sapiens
12-hydroxylauric acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lauric acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 2.5:1
285382
Rattus norvegicus
12-hydroxylauric acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lauric acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 3:1
285382
Rattus norvegicus
12-hydroxylauric acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lauric acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 40:1
285382
Rattus norvegicus
12-hydroxylauric acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lauric acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 6:1
285382
Rattus norvegicus
12-hydroxylauric acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
myristic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 1.2:1
285382
Rattus norvegicus
14-hydroxymyristic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
myristic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 1.6:1
285382
Homo sapiens
14-hydroxymyristic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
myristic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 1.6:1
285382
Rattus norvegicus
14-hydroxymyristic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
myristic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 3:1
285382
Rattus norvegicus
14-hydroxymyristic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
oleic acid + [reduced NADPH-hemoprotein reductase] + O2
-
285382
Homo sapiens
18-hydroxyoleic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
oleic acid + [reduced NADPH-hemoprotein reductase] + O2
-
285382
Rattus norvegicus
18-hydroxyoleic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
palmitic acid + [reduced NADPH-hemoprotein reductase] + O2
-
285382
Rattus norvegicus
16-hydroxypalmitic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
palmitic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 1.6:1
285382
Homo sapiens
16-hydroxypalmitic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
palmitic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 1.6:1
285382
Rattus norvegicus
16-hydroxypalmitic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
palmitic acid + [reduced NADPH-hemoprotein reductase] + O2
regioselectivity of omega:omega-1 hydroxylation is 1:1
285382
Rattus norvegicus
16-hydroxypalmitic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.01
-
arachidonic acid
pH 7.4, 37C
Homo sapiens
0.01
-
oleic acid
pH 7.4, 37C
Homo sapiens
0.01
-
oleic acid
pH 7.4, 37C
Rattus norvegicus
0.02
-
arachidonic acid
pH 7.4, 37C
Rattus norvegicus
0.02
-
oleic acid
pH 7.4, 37C
Rattus norvegicus
0.03
-
arachidonic acid
pH 7.4, 37C
Rattus norvegicus
0.03
-
palmitic acid
pH 7.4, 37C
Rattus norvegicus
0.1
-
arachidonic acid
pH 7.4, 37C
Rattus norvegicus
0.1
-
myristic acid
pH 7.4, 37C
Rattus norvegicus
0.1
-
palmitic acid
pH 7.4, 37C
Rattus norvegicus
0.17
-
palmitic acid
pH 7.4, 37C
Homo sapiens
0.58
-
lauric acid
pH 7.4, 37C
Rattus norvegicus
0.67
-
myristic acid
pH 7.4, 37C
Rattus norvegicus
0.7
-
lauric acid
pH 7.4, 37C
Homo sapiens
0.83
-
myristic acid
pH 7.4, 37C
Homo sapiens
1
-
palmitic acid
pH 7.4, 37C
Rattus norvegicus
1.17
-
myristic acid
pH 7.4, 37C
Rattus norvegicus
1.22
-
lauric acid
pH 7.4, 37C
Rattus norvegicus
3.8
-
lauric acid
pH 7.4, 37C
Rattus norvegicus
3.8
-
myristic acid
pH 7.4, 37C
Rattus norvegicus
10.8
-
lauric acid
pH 7.4, 37C
Rattus norvegicus
Other publictions for EC 1.14.14.80
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
746320
Zhang
Ablation of cytochrome P450 o ...
Mus musculus
Proc. Natl. Acad. Sci. USA
114
3181-3185
2017
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1
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-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
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1
1
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746560
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1
-
-
-
-
-
1
1
-
3
-
4
-
-
-
-
-
3
-
-
4
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
3
-
-
-
-
-
-
-
1
1
-
3
-
-
-
-
-
3
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
744773
Han
Biochemical analysis of recom ...
Homo sapiens
Drug Metab. Pharmacokinet.
31
445-450
2016
1
-
1
-
3
-
-
17
-
1
-
3
-
1
-
-
1
-
-
2
-
-
3
1
1
-
-
17
1
-
-
3
-
-
-
1
-
1
3
-
3
-
-
-
-
17
-
1
-
3
-
-
-
1
-
2
-
-
3
1
1
-
-
17
1
-
-
-
-
-
-
-
18
18
746057
Bjelica
Fatty acid omega-hydroxylases ...
Solanum tuberosum
Plant Cell Rep.
35
2435-2448
2016
-
-
-
-
-
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