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show all sequences of 1.14.14.80

Biochemical analysis of recombinant CYP4A11 allelic variant enzymes W126R, K276T and S353G

Han, S.; Cha, G.S.; Chun, Y.J.; Lee, C.H.; Kim, D.; Yun, C.H.; Drug Metab. Pharmacokinet. 31, 445-450 (2016)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
cytochrome b5
increases the enzyme activity
Homo sapiens
Cloned(Commentary)
Commentary
Organism
gene CYP4A11, recombinant expression of His6-tagged wild-type and mutant enzymes in Escherichia coli
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
K276T
site-directed mutagenesis, the mutant shows increased activity compared to the wild-type enzyme
Homo sapiens
S353G
site-directed mutagenesis, the mutant shows increased activity compared to the wild-type enzyme
Homo sapiens
W126R
site-directed mutagenesis, the mutant W126R variant cannot be expressed in Escherichia coli.
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
Michaelis-Menten kinetics, fatty acids binding constants
Homo sapiens
0.014
-
palmitic acid
pH 7.4, 37°C, recombinant mutant S353G with cytochrome B5
Homo sapiens
0.018
-
myristic acid
pH 7.4, 37°C, recombinant wild-type enzyme with cytochrome B5
Homo sapiens
0.018
-
palmitic acid
pH 7.4, 37°C, recombinant mutant S353G
Homo sapiens
0.019
-
lauric acid
pH 7.4, 37°C, recombinant wild-type enzyme
Homo sapiens
0.021
-
lauric acid
pH 7.4, 37°C, recombinant mutant S353G; pH 7.4, 37°C, recombinant wild-type enzyme, with cytochrome B5
Homo sapiens
0.021
-
palmitic acid
pH 7.4, 37°C, recombinant mutant K276T
Homo sapiens
0.022
-
palmitic acid
pH 7.4, 37°C, recombinant wild-type enzyme; pH 7.4, 37°C, recombinant wild-type enzyme with cytochrome B5
Homo sapiens
0.023
-
lauric acid
pH 7.4, 37°C, recombinant mutant K276T
Homo sapiens
0.026
-
myristic acid
pH 7.4, 37°C, recombinant wild-type enzyme
Homo sapiens
0.029
-
palmitic acid
pH 7.4, 37°C, recombinant mutant K276T with cytochrome B5
Homo sapiens
0.03
-
myristic acid
pH 7.4, 37°C, recombinant mutant K276T
Homo sapiens
0.033
-
lauric acid
pH 7.4, 37°C, recombinant mutant S353G with cytochrome B5
Homo sapiens
0.033
-
myristic acid
pH 7.4, 37°C, recombinant mutant S353G
Homo sapiens
0.037
-
lauric acid
pH 7.4, 37°C, recombinant mutant K276T with cytochrome B5
Homo sapiens
0.037
-
myristic acid
pH 7.4, 37°C, recombinant mutant K276T with cytochrome B5
Homo sapiens
0.045
-
myristic acid
pH 7.4, 37°C, recombinant mutant S353G with cytochrome B5
Homo sapiens
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Fe2+
in heme
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
lauric acid + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
-
12-hydroxylauric acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
myristic acid + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
-
14-hydroxymyrisitic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
palmitic acid + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
-
16-hydroxypalmitic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q02928
-
-
Purification (Commentary)
Commentary
Organism
recombinant His6-tagged wild-type and mutant enzymes from Escherichia coli by nickel affinity chromatography
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
lauric acid + [reduced NADPH-hemoprotein reductase] + O2
-
744773
Homo sapiens
12-hydroxylauric acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
myristic acid + [reduced NADPH-hemoprotein reductase] + O2
-
744773
Homo sapiens
14-hydroxymyrisitic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
palmitic acid + [reduced NADPH-hemoprotein reductase] + O2
-
744773
Homo sapiens
16-hydroxypalmitic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 58500, recombinant His-tagged wild-type enzyme, SDS-PAGE
Homo sapiens
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.055
-
palmitic acid
pH 7.4, 37°C, recombinant wild-type enzyme
Homo sapiens
0.068
-
palmitic acid
pH 7.4, 37°C, recombinant wild-type enzyme with cytochrome B5
Homo sapiens
0.088
-
palmitic acid
pH 7.4, 37°C, recombinant mutant S353G
Homo sapiens
0.1
-
palmitic acid
pH 7.4, 37°C, recombinant mutant K276T
Homo sapiens
0.115
-
palmitic acid
pH 7.4, 37°C, recombinant mutant S353G with cytochrome B5
Homo sapiens
0.117
-
lauric acid
pH 7.4, 37°C, recombinant wild-type enzyme
Homo sapiens
0.157
-
myristic acid
pH 7.4, 37°C, recombinant wild-type enzyme
Homo sapiens
0.188
-
palmitic acid
pH 7.4, 37°C, recombinant mutant K276T with cytochrome B5
Homo sapiens
0.193
-
myristic acid
pH 7.4, 37°C, recombinant wild-type enzyme with cytochrome B5
Homo sapiens
0.258
-
lauric acid
pH 7.4, 37°C, recombinant mutant K276T; pH 7.4, 37°C, recombinant wild-type enzyme, with cytochrome B5
Homo sapiens
0.278
-
myristic acid
pH 7.4, 37°C, recombinant mutant K276T
Homo sapiens
0.423
-
myristic acid
pH 7.4, 37°C, recombinant mutant S353G
Homo sapiens
0.5
-
myristic acid
pH 7.4, 37°C, recombinant mutant K276T with cytochrome B5
Homo sapiens
0.502
-
lauric acid
pH 7.4, 37°C, recombinant mutant S353G
Homo sapiens
0.822
-
myristic acid
pH 7.4, 37°C, recombinant mutant S353G with cytochrome B5
Homo sapiens
0.842
-
lauric acid
pH 7.4, 37°C, recombinant mutant K276T with cytochrome B5
Homo sapiens
0.998
-
lauric acid
pH 7.4, 37°C, recombinant mutant S353G with cytochrome B5
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay at
Homo sapiens
Cofactor
Cofactor
Commentary
Organism
Structure
cytochrome P450
-
Homo sapiens
heme
-
Homo sapiens
NADPH
-
Homo sapiens
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
cytochrome b5
increases the enzyme activity
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
gene CYP4A11, recombinant expression of His6-tagged wild-type and mutant enzymes in Escherichia coli
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
cytochrome P450
-
Homo sapiens
heme
-
Homo sapiens
NADPH
-
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
K276T
site-directed mutagenesis, the mutant shows increased activity compared to the wild-type enzyme
Homo sapiens
S353G
site-directed mutagenesis, the mutant shows increased activity compared to the wild-type enzyme
Homo sapiens
W126R
site-directed mutagenesis, the mutant W126R variant cannot be expressed in Escherichia coli.
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
Michaelis-Menten kinetics, fatty acids binding constants
Homo sapiens
0.014
-
palmitic acid
pH 7.4, 37°C, recombinant mutant S353G with cytochrome B5
Homo sapiens
0.018
-
myristic acid
pH 7.4, 37°C, recombinant wild-type enzyme with cytochrome B5
Homo sapiens
0.018
-
palmitic acid
pH 7.4, 37°C, recombinant mutant S353G
Homo sapiens
0.019
-
lauric acid
pH 7.4, 37°C, recombinant wild-type enzyme
Homo sapiens
0.021
-
lauric acid
pH 7.4, 37°C, recombinant mutant S353G; pH 7.4, 37°C, recombinant wild-type enzyme, with cytochrome B5
Homo sapiens
0.021
-
palmitic acid
pH 7.4, 37°C, recombinant mutant K276T
Homo sapiens
0.022
-
palmitic acid
pH 7.4, 37°C, recombinant wild-type enzyme; pH 7.4, 37°C, recombinant wild-type enzyme with cytochrome B5
Homo sapiens
0.023
-
lauric acid
pH 7.4, 37°C, recombinant mutant K276T
Homo sapiens
0.026
-
myristic acid
pH 7.4, 37°C, recombinant wild-type enzyme
Homo sapiens
0.029
-
palmitic acid
pH 7.4, 37°C, recombinant mutant K276T with cytochrome B5
Homo sapiens
0.03
-
myristic acid
pH 7.4, 37°C, recombinant mutant K276T
Homo sapiens
0.033
-
lauric acid
pH 7.4, 37°C, recombinant mutant S353G with cytochrome B5
Homo sapiens
0.033
-
myristic acid
pH 7.4, 37°C, recombinant mutant S353G
Homo sapiens
0.037
-
lauric acid
pH 7.4, 37°C, recombinant mutant K276T with cytochrome B5
Homo sapiens
0.037
-
myristic acid
pH 7.4, 37°C, recombinant mutant K276T with cytochrome B5
Homo sapiens
0.045
-
myristic acid
pH 7.4, 37°C, recombinant mutant S353G with cytochrome B5
Homo sapiens
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Fe2+
in heme
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
lauric acid + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
-
12-hydroxylauric acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
myristic acid + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
-
14-hydroxymyrisitic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
palmitic acid + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
-
16-hydroxypalmitic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant His6-tagged wild-type and mutant enzymes from Escherichia coli by nickel affinity chromatography
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
lauric acid + [reduced NADPH-hemoprotein reductase] + O2
-
744773
Homo sapiens
12-hydroxylauric acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
myristic acid + [reduced NADPH-hemoprotein reductase] + O2
-
744773
Homo sapiens
14-hydroxymyrisitic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
palmitic acid + [reduced NADPH-hemoprotein reductase] + O2
-
744773
Homo sapiens
16-hydroxypalmitic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 58500, recombinant His-tagged wild-type enzyme, SDS-PAGE
Homo sapiens
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.055
-
palmitic acid
pH 7.4, 37°C, recombinant wild-type enzyme
Homo sapiens
0.068
-
palmitic acid
pH 7.4, 37°C, recombinant wild-type enzyme with cytochrome B5
Homo sapiens
0.088
-
palmitic acid
pH 7.4, 37°C, recombinant mutant S353G
Homo sapiens
0.1
-
palmitic acid
pH 7.4, 37°C, recombinant mutant K276T
Homo sapiens
0.115
-
palmitic acid
pH 7.4, 37°C, recombinant mutant S353G with cytochrome B5
Homo sapiens
0.117
-
lauric acid
pH 7.4, 37°C, recombinant wild-type enzyme
Homo sapiens
0.157
-
myristic acid
pH 7.4, 37°C, recombinant wild-type enzyme
Homo sapiens
0.188
-
palmitic acid
pH 7.4, 37°C, recombinant mutant K276T with cytochrome B5
Homo sapiens
0.193
-
myristic acid
pH 7.4, 37°C, recombinant wild-type enzyme with cytochrome B5
Homo sapiens
0.258
-
lauric acid
pH 7.4, 37°C, recombinant mutant K276T; pH 7.4, 37°C, recombinant wild-type enzyme, with cytochrome B5
Homo sapiens
0.278
-
myristic acid
pH 7.4, 37°C, recombinant mutant K276T
Homo sapiens
0.423
-
myristic acid
pH 7.4, 37°C, recombinant mutant S353G
Homo sapiens
0.5
-
myristic acid
pH 7.4, 37°C, recombinant mutant K276T with cytochrome B5
Homo sapiens
0.502
-
lauric acid
pH 7.4, 37°C, recombinant mutant S353G
Homo sapiens
0.822
-
myristic acid
pH 7.4, 37°C, recombinant mutant S353G with cytochrome B5
Homo sapiens
0.842
-
lauric acid
pH 7.4, 37°C, recombinant mutant K276T with cytochrome B5
Homo sapiens
0.998
-
lauric acid
pH 7.4, 37°C, recombinant mutant S353G with cytochrome B5
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay at
Homo sapiens
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
2.5
-
palmitic acid
pH 7.4, 37°C, recombinant wild-type enzyme
Homo sapiens
3.09
-
palmitic acid
pH 7.4, 37°C, recombinant wild-type enzyme with cytochrome B5
Homo sapiens
4.76
-
palmitic acid
pH 7.4, 37°C, recombinant mutant K276T
Homo sapiens
4.8
-
palmitic acid
pH 7.4, 37°C, recombinant mutant S353G
Homo sapiens
6.04
-
myristic acid
pH 7.4, 37°C, recombinant wild-type enzyme
Homo sapiens
6.16
-
lauric acid
pH 7.4, 37°C, recombinant wild-type enzyme
Homo sapiens
6.48
-
palmitic acid
pH 7.4, 37°C, recombinant mutant K276T with cytochrome B5
Homo sapiens
8.21
-
palmitic acid
pH 7.4, 37°C, recombinant mutant S353G with cytochrome B5
Homo sapiens
9.27
-
myristic acid
pH 7.4, 37°C, recombinant mutant K276T
Homo sapiens
10.72
-
myristic acid
pH 7.4, 37°C, recombinant wild-type enzyme with cytochrome B5
Homo sapiens
11.22
-
lauric acid
pH 7.4, 37°C, recombinant mutant K276T
Homo sapiens
12.27
-
myristic acid
pH 7.4, 37°C, recombinant mutant S353G with cytochrome B5
Homo sapiens
12.29
-
lauric acid
pH 7.4, 37°C, recombinant wild-type enzyme, with cytochrome B5
Homo sapiens
12.8
-
myristic acid
pH 7.4, 37°C, recombinant mutant S353G
Homo sapiens
13.52
-
myristic acid
pH 7.4, 37°C, recombinant mutant K276T with cytochrome B5
Homo sapiens
22.76
-
lauric acid
pH 7.4, 37°C, recombinant mutant K276T with cytochrome B5
Homo sapiens
23.91
-
lauric acid
pH 7.4, 37°C, recombinant mutant S353G
Homo sapiens
30.24
-
lauric acid
pH 7.4, 37°C, recombinant mutant S353G with cytochrome B5
Homo sapiens
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
2.5
-
palmitic acid
pH 7.4, 37°C, recombinant wild-type enzyme
Homo sapiens
3.09
-
palmitic acid
pH 7.4, 37°C, recombinant wild-type enzyme with cytochrome B5
Homo sapiens
4.76
-
palmitic acid
pH 7.4, 37°C, recombinant mutant K276T
Homo sapiens
4.8
-
palmitic acid
pH 7.4, 37°C, recombinant mutant S353G
Homo sapiens
6.04
-
myristic acid
pH 7.4, 37°C, recombinant wild-type enzyme
Homo sapiens
6.16
-
lauric acid
pH 7.4, 37°C, recombinant wild-type enzyme
Homo sapiens
6.48
-
palmitic acid
pH 7.4, 37°C, recombinant mutant K276T with cytochrome B5
Homo sapiens
8.21
-
palmitic acid
pH 7.4, 37°C, recombinant mutant S353G with cytochrome B5
Homo sapiens
9.27
-
myristic acid
pH 7.4, 37°C, recombinant mutant K276T
Homo sapiens
10.72
-
myristic acid
pH 7.4, 37°C, recombinant wild-type enzyme with cytochrome B5
Homo sapiens
11.22
-
lauric acid
pH 7.4, 37°C, recombinant mutant K276T
Homo sapiens
12.27
-
myristic acid
pH 7.4, 37°C, recombinant mutant S353G with cytochrome B5
Homo sapiens
12.29
-
lauric acid
pH 7.4, 37°C, recombinant wild-type enzyme, with cytochrome B5
Homo sapiens
12.8
-
myristic acid
pH 7.4, 37°C, recombinant mutant S353G
Homo sapiens
13.52
-
myristic acid
pH 7.4, 37°C, recombinant mutant K276T with cytochrome B5
Homo sapiens
22.76
-
lauric acid
pH 7.4, 37°C, recombinant mutant K276T with cytochrome B5
Homo sapiens
23.91
-
lauric acid
pH 7.4, 37°C, recombinant mutant S353G
Homo sapiens
30.24
-
lauric acid
pH 7.4, 37°C, recombinant mutant S353G with cytochrome B5
Homo sapiens
Other publictions for EC 1.14.14.80
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
746320
Zhang
Ablation of cytochrome P450 o ...
Mus musculus
Proc. Natl. Acad. Sci. USA
114
3181-3185
2017
-
1
-
-
-
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-
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-
1
-
-
-
-
-
1
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
746560
Uehara
Marmoset cytochrome P450 4A11 ...
Callithrix jacchus
Xenobiotica
47
553-561
2017
-
-
1
-
-
-
-
-
1
1
-
3
-
4
-
-
-
-
-
3
-
-
4
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
3
-
-
-
-
-
-
-
1
1
-
3
-
-
-
-
-
3
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
744773
Han
Biochemical analysis of recom ...
Homo sapiens
Drug Metab. Pharmacokinet.
31
445-450
2016
1
-
1
-
3
-
-
17
-
1
-
3
-
1
-
-
1
-
-
2
-
-
3
1
1
-
-
17
1
-
-
3
-
-
-
1
-
1
3
-
3
-
-
-
-
17
-
1
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3
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