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Literature summary for 1.14.14.91 extracted from

  • Li, W.; Yang, Y.; Qiao, C.; Zhang, G.; Luo, Y.
    Functional characterization of phenylalanine ammonia-lyase- and cinnamate 4-hydroxylase-encoding genes from Lycoris radiata, a galanthamine-producing plant (2018), Int. J. Biol. Macromol., 117, 1264-1279 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli Lycoris radiata

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Lycoris radiata

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
trans-cinnamate + [reduced NADPH-hemoprotein reductase] + O2 Lycoris radiata the enzyme is involved in the biosynthesis of galanthamine 4-hydroxycinnamate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Lycoris radiata A0A2Z4I2V7
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Lycoris radiata

Source Tissue

Source Tissue Comment Organism Textmining
bulb intermediate transcript level Lycoris radiata
-
flower high transcript level, the transcriptional levels of LrPAL3 is positively associated with the galanthamine contents within the leaves and flowers, which suggested that the expression and function is coregulated and involved in the biosynthesis of galanthamine Lycoris radiata
-
leaf intermediate transcript level. The transcriptional levels of LrPAL3 is positively associated with the galanthamine contents within the leaves and flowers, which suggested that the expression and function is coregulated and involved in the biosynthesis of galanthamine Lycoris radiata
-
root low transcript level Lycoris radiata
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trans-cinnamate + [reduced NADPH-hemoprotein reductase] + O2
-
Lycoris radiata 4-hydroxycinnamate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?
trans-cinnamate + [reduced NADPH-hemoprotein reductase] + O2 the enzyme is involved in the biosynthesis of galanthamine Lycoris radiata 4-hydroxycinnamate + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
C4H
-
Lycoris radiata
cinnamic acid 4-hydroxylase
-
Lycoris radiata
LrC4H
-
Lycoris radiata

General Information

General Information Comment Organism
metabolism the enzyme is involved in the biosynthesis of galanthamine, a Amaryllidaceae alkaloid, that is a clinically used drug for the treatment of Alzheimer's disease Lycoris radiata