BRENDA - Enzyme Database show
show all sequences of 1.14.14.94

Prostaglandin and leukotriene omega-hydroxylases

Kikuta, Y.; Kusunose, E.; Kusunose, M.; Prostaglandins 68-69, 345-362 (2002)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression in yeast; expression in yeast cells, CYP4F3
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00064
-
leukotriene B4
CYP4F3
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Homo sapiens
-
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
additional information
-
the isolated cDNA encodes a protein of 520 amino acids with 59805 Da, CYP4F3
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
arachidonate + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
the enzyme is the principal arachidonate omega-hydroxylase in liver, CYP4F2
20-hydroxy-5,8,11,14-eicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
the enzyme plays a critical role in regulating the biological effect of leukotriene B4, CYP4F3
20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
additional information
Homo sapiens
CYP4F3B and CYP4F2 may function collaboratively as 20-HETE synthetase as well as omega-hydroxylases for leukotiene b4 and other lipoxygenase-dependent eicosanoids in human liver and other tissues
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Purification (Commentary)
Commentary
Organism
CYP4F3
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
heart
CYP4F11
Homo sapiens
-
ileum
CYP4F3B is the predominant CYP4F isoform
Homo sapiens
-
kidney
CYP4F11; CYP4F2; CYP4F3B
Homo sapiens
-
liver
CYP4F11; CYP4F2; CYP4F3B is the predominant CYP4F isoform; mRNA for CYP4F8 detected
Homo sapiens
-
additional information
CYP4F2 is not expressed in myeloid cells, polymorphonuclear leukocyte; no expression of CYP4F8 in leukocytes
Homo sapiens
-
polymorphonuclear leukocyte
CYP4F3 is specifically expressed in. CYP4F3 is restricted to myeloid cells
Homo sapiens
-
prostate gland
mRNA for CYP4F8 detected
Homo sapiens
-
seminal vesicle
CYP4F8
Homo sapiens
-
skeletal muscle
CYP4F11
Homo sapiens
-
skin
CYP4F2
Homo sapiens
-
Storage Stability
Storage Stability
Organism
-70°C, 50% losss of activity after 3 days
Homo sapiens
-70°C, no loss of activity with highly purified preparations even after 4 years
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(E,Z,Z,Z)-8-hydroxy-5,9,11,14-eicosatetraenoic acid + [reduced NADPH-hemoprotein reductase] + O2
CYP4F2
660409
Homo sapiens
?
-
-
-
?
12-hydroxy-5,8,10,14-eicosatetraenoic acid + [reduced NADPH-hemoprotein reductase] + O2
CYP4F2
660409
Homo sapiens
?
-
-
-
?
20-hydroxy-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3
660409
Homo sapiens
?
-
-
-
?
5-hydroxy-6,8,11,14-eicosatetraenoic acid + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3
660409
Homo sapiens
?
-
-
-
?
6-trans-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F2
660409
Homo sapiens
?
-
-
-
?
6-trans-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3
660409
Homo sapiens
?
-
-
-
?
9,11-diazo-15-deoxy-prostaglandin H2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F8
660409
Homo sapiens
?
-
-
-
?
9,11-epoxymethano-prostaglandin H2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F8
660409
Homo sapiens
?
-
-
-
?
arachidonate + [reduced NADPH-hemoprotein reductase] + O2
-
660409
Homo sapiens
20-hydroxy-5,8,11,14-eicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
arachidonate + [reduced NADPH-hemoprotein reductase] + O2
very poor substrate
660409
Homo sapiens
20-hydroxy-5,8,11,14-eicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
arachidonate + [reduced NADPH-hemoprotein reductase] + O2
the enzyme is the principal arachidonate omega-hydroxylase in liver, CYP4F2
660409
Homo sapiens
20-hydroxy-5,8,11,14-eicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
-
660409
Homo sapiens
18(R)-hydroxyarachidonate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
660409
Homo sapiens
20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
the enzyme plays a critical role in regulating the biological effect of leukotriene B4, CYP4F3
660409
Homo sapiens
20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
yielding omega-COOH-leukotriene B4 via omega-hydroxy-leukotriene B4 and omega-CHO-leukotriene B4, CYP4F3
660409
Homo sapiens
20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lipoxin A4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3 preferentially omega-jydroxylates lipoxin B4 over lipoxin A4
660409
Homo sapiens
?
-
-
-
?
lipoxin A4 + [reduced NADPH-hemoprotein reductase] + O2
no omega-hydroxylation of LXB4, CYP4F2
660409
Homo sapiens
?
-
-
-
?
lipoxin B4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3 preferentially omega-jydroxylates lipoxin B4 over lipoxin A4
660409
Homo sapiens
?
-
-
-
?
additional information
CYP4F3B and CYP4F2 may function collaboratively as 20-HETE synthetase as well as omega-hydroxylases for leukotiene b4 and other lipoxygenase-dependent eicosanoids in human liver and other tissues
660409
Homo sapiens
?
-
-
-
-
prostaglandin H1 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F8
660409
Homo sapiens
19-hydroxy-prostaglandin H1 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
prostaglandin H2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F8
660409
Homo sapiens
19-hydroxy-prostaglandin H2 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in yeast; expression in yeast cells, CYP4F3
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00064
-
leukotriene B4
CYP4F3
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Homo sapiens
-
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
additional information
-
the isolated cDNA encodes a protein of 520 amino acids with 59805 Da, CYP4F3
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
arachidonate + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
the enzyme is the principal arachidonate omega-hydroxylase in liver, CYP4F2
20-hydroxy-5,8,11,14-eicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
the enzyme plays a critical role in regulating the biological effect of leukotriene B4, CYP4F3
20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
additional information
Homo sapiens
CYP4F3B and CYP4F2 may function collaboratively as 20-HETE synthetase as well as omega-hydroxylases for leukotiene b4 and other lipoxygenase-dependent eicosanoids in human liver and other tissues
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
CYP4F3
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
heart
CYP4F11
Homo sapiens
-
ileum
CYP4F3B is the predominant CYP4F isoform
Homo sapiens
-
kidney
CYP4F11; CYP4F2; CYP4F3B
Homo sapiens
-
liver
CYP4F11; CYP4F2; CYP4F3B is the predominant CYP4F isoform; mRNA for CYP4F8 detected
Homo sapiens
-
additional information
CYP4F2 is not expressed in myeloid cells, polymorphonuclear leukocyte; no expression of CYP4F8 in leukocytes
Homo sapiens
-
polymorphonuclear leukocyte
CYP4F3 is specifically expressed in. CYP4F3 is restricted to myeloid cells
Homo sapiens
-
prostate gland
mRNA for CYP4F8 detected
Homo sapiens
-
seminal vesicle
CYP4F8
Homo sapiens
-
skeletal muscle
CYP4F11
Homo sapiens
-
skin
CYP4F2
Homo sapiens
-
Storage Stability (protein specific)
Storage Stability
Organism
-70°C, 50% losss of activity after 3 days
Homo sapiens
-70°C, no loss of activity with highly purified preparations even after 4 years
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(E,Z,Z,Z)-8-hydroxy-5,9,11,14-eicosatetraenoic acid + [reduced NADPH-hemoprotein reductase] + O2
CYP4F2
660409
Homo sapiens
?
-
-
-
?
12-hydroxy-5,8,10,14-eicosatetraenoic acid + [reduced NADPH-hemoprotein reductase] + O2
CYP4F2
660409
Homo sapiens
?
-
-
-
?
20-hydroxy-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3
660409
Homo sapiens
?
-
-
-
?
5-hydroxy-6,8,11,14-eicosatetraenoic acid + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3
660409
Homo sapiens
?
-
-
-
?
6-trans-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F2
660409
Homo sapiens
?
-
-
-
?
6-trans-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3
660409
Homo sapiens
?
-
-
-
?
9,11-diazo-15-deoxy-prostaglandin H2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F8
660409
Homo sapiens
?
-
-
-
?
9,11-epoxymethano-prostaglandin H2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F8
660409
Homo sapiens
?
-
-
-
?
arachidonate + [reduced NADPH-hemoprotein reductase] + O2
-
660409
Homo sapiens
20-hydroxy-5,8,11,14-eicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
arachidonate + [reduced NADPH-hemoprotein reductase] + O2
very poor substrate
660409
Homo sapiens
20-hydroxy-5,8,11,14-eicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
arachidonate + [reduced NADPH-hemoprotein reductase] + O2
the enzyme is the principal arachidonate omega-hydroxylase in liver, CYP4F2
660409
Homo sapiens
20-hydroxy-5,8,11,14-eicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
-
660409
Homo sapiens
18(R)-hydroxyarachidonate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
660409
Homo sapiens
20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
the enzyme plays a critical role in regulating the biological effect of leukotriene B4, CYP4F3
660409
Homo sapiens
20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
yielding omega-COOH-leukotriene B4 via omega-hydroxy-leukotriene B4 and omega-CHO-leukotriene B4, CYP4F3
660409
Homo sapiens
20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
lipoxin A4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3 preferentially omega-jydroxylates lipoxin B4 over lipoxin A4
660409
Homo sapiens
?
-
-
-
?
lipoxin A4 + [reduced NADPH-hemoprotein reductase] + O2
no omega-hydroxylation of LXB4, CYP4F2
660409
Homo sapiens
?
-
-
-
?
lipoxin B4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3 preferentially omega-jydroxylates lipoxin B4 over lipoxin A4
660409
Homo sapiens
?
-
-
-
?
additional information
CYP4F3B and CYP4F2 may function collaboratively as 20-HETE synthetase as well as omega-hydroxylases for leukotiene b4 and other lipoxygenase-dependent eicosanoids in human liver and other tissues
660409
Homo sapiens
?
-
-
-
-
prostaglandin H1 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F8
660409
Homo sapiens
19-hydroxy-prostaglandin H1 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
prostaglandin H2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F8
660409
Homo sapiens
19-hydroxy-prostaglandin H2 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Other publictions for EC 1.14.14.94
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741555
Johnson
Cytochrome P450 omega-hydroxy ...
Homo sapiens
Adv. Pharmacol.
74
223-262
2015
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3
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1
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1
1
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712833
Bardowell
Common variants of cytochrome ...
Homo sapiens
J. Nutr.
140
1901-1906
2010
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1
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2
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1
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1
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2
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1
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6
1
1
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1
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1
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2
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1
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1
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1
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6
1
1
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1
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1
1
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-
701913
Du
20-Hydroxylation is the CYP-de ...
Homo sapiens, Mus musculus, Mus musculus CD-1
Arch. Biochem. Biophys.
484
80-86
2009
1
-
1
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1
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1
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9
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4
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1
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1
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1
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4
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1
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-
-
2
-
-
2
-
-
703413
Zhao
Induction of CYP4F3 by benzene ...
Homo sapiens
Drug Metab. Dispos.
37
282-291
2009
3
1
-
-
-
-
-
-
-
-
-
-
-
2
-
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5
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1
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3
1
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5
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1
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-
-
-
-
-
1
1
-
-
-
684731
Hirani
Expression of CYP4F2 in human ...
Homo sapiens
Arch. Biochem. Biophys.
478
59-68
2008
-
-
1
-
-
-
-
-
1
-
-
1
-
3
-
-
1
-
-
5
-
-
1
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1
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1
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-
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1
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1
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1
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1
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5
-
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1
-
1
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-
-
1
-
-
-
-
-
-
-
-
-
703013
Mao
Differential modulation of leu ...
Homo sapiens
Cancer Prev. Res. (Phila)
1
266-274
2008
1
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
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-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
685340
Kikuta
Expression and physiological f ...
Homo sapiens
Biochim. Biophys. Acta
1771
1439-1445
2007
-
-
-
-
-
-
-
2
-
1
-
1
-
3
-
-
-
-
-
6
-
-
6
-
1
-
-
-
1
-
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1
-
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-
1
-
-
-
-
-
-
2
-
1
-
1
-
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-
-
6
-
-
6
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
689399
Stec
Functional polymorphism in hum ...
Homo sapiens
Physiol. Genomics
30
74-81
2007
-
-
1
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3
-
-
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-
1
-
2
-
2
-
-
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-
-
1
-
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3
-
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-
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1
-
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1
1
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3
-
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1
-
2
-
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-
-
1
-
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3
-
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