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Literature summary for 1.14.14.94 extracted from

  • Christmas, P.; Tolentino, K.; Primo, V.; Berry, K.Z.; Murphy, R.C.; Chen, M.; Lee, D.M.; Soberman, R.J.
    Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2 hydroxylase in mouse polymorphonuclear leukocytes: identification as the functional orthologue of human polymorphonuclear leukocyte CYP4F3A in the down-regulation of responses to LTB4 (2006), J. Biol. Chem., 281, 7189-7196.
    View publication on PubMed
Search for more literature for 1.14.14.94

Activating Compound

Activating Compound Comment Organism Structure
additional information CYP4F18 expression is induced in bone marrow-derived dendritic cells by bacterial lipopolysaccharide, a ligand for TLR4, and by poly(I-C), a ligand for TLR3 Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
gene Cyp4f18, expression analysis of CYP4F18 in different cell types, recombinant expression of the enzyme in Spodoptera frugiperda Sf9 cell microsomes via baculovirus transfection system Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information in vivo inhibition of CYP4F18 results in a marked increase in calcium flux and a 220% increase in the chemotactic response of mouse PMN to LTB4 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH-hemoprotein reductase] + O2 Mus musculus LTB4 inactivation, in vivo inhibition of CYP4F18 results in a marked increase in calcium flux and a 220% increases in the chemotactic response of mouse polymorphonuclear leukocytes to LTB4 (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?
additional information Mus musculus CYP4F18 is a critical protein in the regulation of LTB4 metabolism, the enzyme is active in down-regulation of responses to leukotriene B4, i.e. LTB4, leukotriene B4 is a potent chemoattractant for polymorphonuclear leukocytes and other cells, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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 gene Cyp4f18
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Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
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 Mus musculus
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dendritic cell bone marrow-derived, in vitro differentiation Mus musculus
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leukocyte polymorphonuclear Mus musculus
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additional information tissue-specific expression, expression analysis of CYP4F18 in different cell types, tissue distribution, overview Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH-hemoprotein reductase] + O2
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 Mus musculus (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH-hemoprotein reductase] + O2 LTB4 inactivation, in vivo inhibition of CYP4F18 results in a marked increase in calcium flux and a 220% increases in the chemotactic response of mouse polymorphonuclear leukocytes to LTB4 Mus musculus (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
additional information CYP4F18 is a critical protein in the regulation of LTB4 metabolism, the enzyme is active in down-regulation of responses to leukotriene B4, i.e. LTB4, leukotriene B4 is a potent chemoattractant for polymorphonuclear leukocytes and other cells, overview Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
CYP4F18
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 Mus musculus
cytochrome P-450 4F18
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 Mus musculus
leukotriene B4 omega-1/omega-2 hydroxylase
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 Mus musculus