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Literature summary for 1.14.14.94 extracted from

  • Stec, D.E.; Roman, R.J.; Flasch, A.; Rieder, M.J.
    Functional polymorphism in human CYP4F2 decreases 20-HETE production (2007), Physiol. Genomics, 30, 74-81.
    View publication on PubMed
Search for more literature for 1.14.14.94

Cloned(Commentary)

Cloned (Comment) Organism
wild-type and mutant DNA and amino acid sequence determinations, functional nonsynonymous polymorphisms, overview, expression of wild-type and mutant genes in Spodoptera frugiperda Sf9 cells using the baculovirus transfection method Homo sapiens

Protein Variants

Protein Variants Comment Organism
V433M the functional polymorphism in human Cyp4F2 decreases 20-hydroxyeicosatetraenoic acid production, but does not influence the omega-hydroxylation of leukotriene B4, screening and genotyping of African and European Americans, overview Homo sapiens
W12G the mutant enzyme activity is similar to the wild-type enzyme, screening and genotyping of African and European Americans, overview Homo sapiens
W12G/V433M the functional polymorphism in human Cyp4F2 decreases 20-hydroxyeicosatetraenoic acid production, but does not influence the omega-hydroxylation of leukotriene B4, screening and genotyping of African and European Americans, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ a cytochrome P450 enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
additional information Homo sapiens cytochrome P450 4F2 gene encodes for the major CYP enzyme responsible for the synthesis of 20-hydroxyeicosatetraenoic acid in the human kidney ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P78329
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens ?
-
 ?
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
additional information cytochrome P450 4F2 gene encodes for the major CYP enzyme responsible for the synthesis of 20-hydroxyeicosatetraenoic acid in the human kidney Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CYP4F2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
 Homo sapiens