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Literature summary for 1.14.14.94 extracted from
- 20-Hydroxylation is the CYP-dependent and retinoid-inducible leukotriene B4 inactivation pathway in human and mouse skin cells (2009), Arch. Biochem. Biophys., 484, 80-86.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| all-trans-retinoic acid | after 6 days of retinoid exposure, cutaneous transcripts arising from Cyp4f39 are up-regulated. No changes in transcript abundance for the Cyp4f16, 4f17, and 4f18 genes | Mus musculus |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| all-trans-retinoic acid | after 6 days of retinoid exposure, cutaneous transcripts arising from Cyp4f13, 4f14, and 4f37 are down-regulated. No changes in transcript abundance for the Cyp4f16, 4f17, and 4f18 genes | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | from full-thickness skin | Mus musculus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
CD-1 strain | - |
| Mus musculus CD-1 | - |
CD-1 strain | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epidermis | - |
Homo sapiens | - |
| NHEK cell | exhibits greater leukotriene B4 hydroxylase activities than fresh skin tissues of either species | Homo sapiens | - |
| skin | - |
Homo sapiens | - |
| skin | transcript abundance is highest for Cyp4f13 and 4f16 genes, lowest for Cyp4f14, 4f17, and 4f37, and intermediate for Cyp4f18 and 4f39. Transcripts arising from Cyp4f15 are highly variable, ranging from intermediate to undetectable levels in individual mice. Transcripts arising from Cyp4f40 are present, but levels are too low to measure reliably in most mice | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2 | all recombinant proteins generate product I from leukotriene B4, which in all cases is indistinguishable from the 20-hydroxy-leukotriene B4 reference compound assayed under similar conditions. CYP4F3A is the most efficient leukotriene B4 20-hydroxylase. CYP4F3A and 4F3B generate a secondary product, which is 20-COOH leukotriene B4 derived from 20-hydroxy-leukotriene B4. CYP4F12 is least efficient, generating several additional products. Product I derived from CYP4F3A and that from epidermal keratinocytes are identical to the 20-hydroxy-leukotriene B4 reference compound | Homo sapiens | 20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP4F12 | - |
Homo sapiens |
| CYP4F13 | - |
Mus musculus |
| CYP4F14 | - |
Mus musculus |
| CYP4F15 | - |
Mus musculus |
| CYP4F16 | - |
Mus musculus |
| CYP4F17 | - |
Mus musculus |
| CYP4F18 | - |
Mus musculus |
| CYP4F2 | - |
Homo sapiens |
| CYP4F37 | - |
Mus musculus |
| CYP4F39 | - |
Mus musculus |
| CYP4F3A | - |
Homo sapiens |
| CYP4F3B | - |
Homo sapiens |
| CYP4F40 | - |
Mus musculus |
| LTB4 hydroxylase | - |
Mus musculus |
| LTB4 hydroxylase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | after 6 days of retinoid exposure, cutaneous transcripts arising from Cyp4f13, 4f14, and 4f37 are down-regulated | down |
| Mus musculus | after 6 days of retinoid exposure, cutaneous transcripts arising from Cyp4f39 are up-regulated | up |
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