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Literature summary for 1.14.14.94 extracted from

  • Mao, J.T.; Tashkin, D.P.; Tsu, I.H.; Serio, K.J.
    Differential modulation of leukotriene B4 synthesis and degradation in human bronchoalveolar lavage cells by lipopolysaccharide and tobacco smoke (2008), Cancer Prev. Res. (Phila), 1, 266-274.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
lipopolysaccharide upregulates expression and activity of LTB4OH in ex-smokers in a dose-dependent manner, but not in smokers. In vitro smoke exposure of ex-smokers' bronchoalveolar lavage cells abrogates the lipopolysaccharide-induced up-regulation of LTB4OH mRNA expression, thus tobacco smoke alters bronchoalveolar lavage cell LTB4OH mRNA expression in response to lipopolysaccharide exposure Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
17-octadecynoic acid
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bronchoalveolar lavage ex-smokers express significantly higher LTB4OH mRNA levels than smokers Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
LTB4 omega-hydroxylase
-
 Homo sapiens
LTB4OH
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function by regulating the balance of leukotriene B4 in the lung, LTB4OH may function as a suppressor of lung carcinogenesis Homo sapiens