Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ancymidol | - |
Corydalis vaginans | |
CO | reversible by light | Corydalis vaginans | |
cytochrome c | - |
Corydalis vaginans | |
ketoconazole | - |
Corydalis vaginans | |
Metyrapone | - |
Corydalis vaginans | |
Prochloraz | - |
Corydalis vaginans |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0125 | - |
cis-N-methylcanadine | - |
Corydalis vaginans | |
0.0625 | - |
NADPH | - |
Corydalis vaginans |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | membrane bound | Corydalis vaginans | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-cis-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 | Corydalis vaginans | (R)-cis/trans-N-methyl-canadine is no substrate | allocryptopine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(S)-cis-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 | Corydalis vaginans | hydroxylation in benzylisoquinoline metabolism | allocryptopine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Corydalis vaginans | - |
papaveraceae | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
(S)-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 = allocryptopine + [oxidized NADPH-hemoprotein reductase] + H2O | stereo- and regiospecificity | Corydalis vaginans |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell suspension culture | - |
Corydalis vaginans | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0255 | - |
- |
Corydalis vaginans |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-cis-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 | no activity without molecular oxygen | Corydalis vaginans | allocryptopine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(S)-cis-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 | (R)-cis/trans-N-methyl-canadine is no substrate | Corydalis vaginans | allocryptopine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(S)-cis-N-methylcanadine + [reduced NADPH-hemoprotein reductase] + O2 | hydroxylation in benzylisoquinoline metabolism | Corydalis vaginans | allocryptopine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(S)-cis-N-methylcorydalmine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Corydalis vaginans | muramine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(S)-cis-N-methylstylopine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Corydalis vaginans | protopine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(S)-cis-N-methyltetrahydropalmitine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Corydalis vaginans | muramine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(S)-cis-N-methyltetrahydrothalifendine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Corydalis vaginans | thalictrisine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
(S)-N-methylcanadine + NADPH + H+ + O2 | - |
Corydalis vaginans | allocryptopine + NADP+ + H2O | - |
r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
- |
Corydalis vaginans |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
10 | 45 | half-maximal activity at 10°C and 45°C | Corydalis vaginans |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
- |
Corydalis vaginans |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 9.7 | half-maximal activity at pH 6.5 and pH 9.7 | Corydalis vaginans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | - |
Corydalis vaginans |