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Literature summary for 1.14.15.15 extracted from

  • Okuda, K.; Masumoto, O.; Ohyama, Y.
    Purification and characterization of 5beta-cholestane-3alpha,7alpha,12alpha-triol 27-hydroxylase from female rat liver mitochondria (1988), J. Biol. Chem., 263, 18138-18142.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
7,8-Benzoflavone 68% inhibition at 0.04 mM Rattus norvegicus
Aminoglutethimide slight inhibition Rattus norvegicus
CO
-
Rattus norvegicus
p-chloromercuribenzoate complete inhibition at 0.08 mM Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0063
-
5beta-cholestane-3alpha,7alpha,12alpha-triol
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52500
-
SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
female rat
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.431
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2
-
Rattus norvegicus 5beta-cholestane-3alpha,7alpha,12alpha,27-tetrol + oxidized adrenodoxin + H2O
-
?
5beta-cholestane-3alpha,7alpha-diol + reduced adrenodoxin + O2
-
Rattus norvegicus ?
-
?
cholesterol + reduced adrenodoxin + O2
-
Rattus norvegicus ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0117
-
cholesterol
-
Rattus norvegicus
0.217
-
5beta-cholestane-3alpha,7alpha-diol
-
Rattus norvegicus
0.592
-
5beta-cholestane-3alpha,7alpha,12alpha-triol
-
Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
Rattus norvegicus