Cloned (Comment) | Organism |
---|---|
gene CYP27A1, cloned from liver cDNA, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis | Macaca fascicularis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + reduced adrenodoxin + O2 | Macaca fascicularis | - |
27-hydroxycholesterol + oxidized adrenodoxin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Macaca fascicularis | B8K1T2 | gene CYP27A1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Macaca fascicularis | - |
brain | - |
Macaca fascicularis | - |
heart | - |
Macaca fascicularis | - |
kidney | - |
Macaca fascicularis | - |
liver | CYP27A1 is most abundantly expressed in liver | Macaca fascicularis | - |
lung | - |
Macaca fascicularis | - |
additional information | tissue expression pattern, overview | Macaca fascicularis | - |
ovary | - |
Macaca fascicularis | - |
small intestine | - |
Macaca fascicularis | - |
testis | - |
Macaca fascicularis | - |
uterus | - |
Macaca fascicularis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + reduced adrenodoxin + O2 | - |
Macaca fascicularis | 27-hydroxycholesterol + oxidized adrenodoxin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP27A1 | - |
Macaca fascicularis |
sterol 27-hydroxylase | - |
Macaca fascicularis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
adrenodoxin | - |
Macaca fascicularis |
General Information | Comment | Organism |
---|---|---|
physiological function | CYP27A1, sterol 27-hydroxylase, catalyzes the oxidation of cholesterol to 27-hydroxycholesterol in the bile acid biosynthesis and participates in other processes of cholesterol homeostasis. CYP27A1 is also involved in metabolism of vitamin D as vitamin D hydroxylase | Macaca fascicularis |