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Literature summary for 1.14.15.15 extracted from

  • Uno, Y.; Hosaka, S.; Yamazaki, H.
    Identification and analysis of CYP7A1, CYP17A1, CYP20A1, CYP27A1 and CYP51A1 in cynomolgus macaques (2014), J. Vet. Med. Sci., 76, 1647-1650.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene CYP27A1, cloned from liver cDNA, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis Macaca fascicularis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + reduced adrenodoxin + O2 Macaca fascicularis
-
27-hydroxycholesterol + oxidized adrenodoxin + H2O
-
?

Organism

Organism UniProt Comment Textmining
Macaca fascicularis B8K1T2 gene CYP27A1
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Macaca fascicularis
-
brain
-
Macaca fascicularis
-
heart
-
Macaca fascicularis
-
kidney
-
Macaca fascicularis
-
liver CYP27A1 is most abundantly expressed in liver Macaca fascicularis
-
lung
-
Macaca fascicularis
-
additional information tissue expression pattern, overview Macaca fascicularis
-
ovary
-
Macaca fascicularis
-
small intestine
-
Macaca fascicularis
-
testis
-
Macaca fascicularis
-
uterus
-
Macaca fascicularis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + reduced adrenodoxin + O2
-
Macaca fascicularis 27-hydroxycholesterol + oxidized adrenodoxin + H2O
-
?

Synonyms

Synonyms Comment Organism
CYP27A1
-
Macaca fascicularis
sterol 27-hydroxylase
-
Macaca fascicularis

Cofactor

Cofactor Comment Organism Structure
adrenodoxin
-
Macaca fascicularis

General Information

General Information Comment Organism
physiological function CYP27A1, sterol 27-hydroxylase, catalyzes the oxidation of cholesterol to 27-hydroxycholesterol in the bile acid biosynthesis and participates in other processes of cholesterol homeostasis. CYP27A1 is also involved in metabolism of vitamin D as vitamin D hydroxylase Macaca fascicularis