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Literature summary for 1.14.15.16 extracted from

  • Sawada, N.; Kusudo, T.; Sakaki, T.; Hatakeyama, S.; Hanada, M.; Abe, D.; Kamao, M.; Okano, T.; Ohta, M.; Inouye, K.
    Novel metabolism of 1 alpha,25-dihydroxyvitamin D3 with C24-C25 bond cleavage catalyzed by human CYP24A1 (2004), Biochemistry, 43, 4530-4537.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli JM109 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 after hydrogen abstraction of the C-23 position of 1alpha,25-dihydroxyvitamin D3, part of the substrate-radical intermediate is converted into 25,26,27-trinor-23-ene-1alpha-hydroxyvitamin D3, while a major part of them is converted into 1alpha,23,25-trihydroxyvitamin D3 Homo sapiens 1alpha,23,25-trihydroxyvitamin D3 + 25,26,27-trinor-23-ene-1alpha-hydroxyvitamin D3 + NADP+ + H2O
-
?
25-hydroxyvitamin D3 + NADPH + H+ + O2
-
Homo sapiens 25,26,27-trinor-23-ene-vitamin D3 + NADP+ + H2O the metabolite 25,26,27-trinor-23-ene-vitamin D3 is closely related with the C-23 hydroxylation pathway ?

Synonyms

Synonyms Comment Organism
CYP24A1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
Homo sapiens
NADPH
-
Homo sapiens