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Literature summary for 1.14.15.18 extracted from

  • Ghazarian, J.G.; Jefcoate, C.R.; Knutson, J.C.; Orme-Johnson, W.H.; DeLuca, H.F.
    Mitochondrial cytochrome P450. A component of chick kidney 25-hydrocholecalciferol-1alpha-hydroxylase (1974), J. Biol. Chem., 249, 3026-3033.
    View publication on PubMed
Search for more literature for 1.14.15.18

Inhibitors

Inhibitors Comment Organism Structure
Aminoglutethimide enzyme of intact mitochondria Gallus gallus
metapyrone
-
 Gallus gallus
Metyrapone enzyme of intact mitochondria Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Gallus gallus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
25-hydroxycholecalciferol + NADPH + O2 Gallus gallus
-
 calcitriol + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
25-hydroxycholecalciferol + NADPH + O2
-
 Gallus gallus calcitriol + NADP+ + H2O
-
 ?
calcidiol + NADPH + O2 highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol Gallus gallus calcitriol + NADP+ + H2O calcitriol is identical with 1,25-dihydroxycholecalciferol ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Gallus gallus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.16
-
 metapyrone
-
 Gallus gallus
1.1
-
 Aminoglutethimide
-
 Gallus gallus