Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2 | Mycobacterium tuberculosis | - |
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | - |
? | |
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2 | Mycobacterium tuberculosis H37Rv | - |
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WPN7 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WPN7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2 | - |
Mycobacterium tuberculosis | omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | - |
? | |
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2 | - |
Mycobacterium tuberculosis H37Rv | omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cyp128 | - |
Mycobacterium tuberculosis |
Rv2268c | - |
Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
physiological function | Cyp128 and sulfotransferase Stf 3 are sufficient for the biosynthesis of sulfomenaquinone from menaquinone in recombinant Mycobacterium smegmatis. In a mouse model of infection the loss of Cyp128 exhibits a hypervirulent phenotype similar to that in previous studies of the Stf 3 mutant | Mycobacterium tuberculosis |