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Literature summary for 1.14.15.5 extracted from

  • Raman, P.B.; Sharma, D.C.; Dorfman, R.I.
    Studies on aldosterone biosynthesis in vitro (1966), Biochemistry, 5, 1795-1804.
    View publication on PubMed
Search for more literature for 1.14.15.5

General Stability

General Stability Organism
lyophilization, mitochondria lose 90% activity Cavia porcellus
lyophilization, mitochondria lose 90% activity Bos taurus
lyophilization, mitochondria lose 90% activity Ovis aries

Inhibitors

Inhibitors Comment Organism Structure
1,2-Bis(3-pyridyl)-2-methyl-1-propanone SU 4885 Bos taurus
1,2-Bis(3-pyridyl)-2-methyl-1-propanone SU 4885 Cavia porcellus
1,2-Bis(3-pyridyl)-2-methyl-1-propanone SU 4885 Ovis aries
18-hydroxycorticosterone product inhibition Bos taurus
18-hydroxycorticosterone product inhibition Cavia porcellus
18-hydroxycorticosterone product inhibition Ovis aries
3-(1,2, 3,4-Tetrahydr-1-oxo-2-naphthyl)pyridine SU 9055 Bos taurus
3-(1,2, 3,4-Tetrahydr-1-oxo-2-naphthyl)pyridine SU 9055 Cavia porcellus
3-(1,2, 3,4-Tetrahydr-1-oxo-2-naphthyl)pyridine SU 9055 Ovis aries
Co2+
-
 Bos taurus
Co2+
-
 Cavia porcellus
Co2+
-
 Ovis aries
Cu2+
-
 Bos taurus
Cu2+
-
 Cavia porcellus
Cu2+
-
 Ovis aries
diethyldithiocarbamate
-
 Bos taurus
diethyldithiocarbamate
-
 Cavia porcellus
diethyldithiocarbamate
-
 Ovis aries
Fe3+
-
 Bos taurus
Fe3+
-
 Cavia porcellus
Fe3+
-
 Ovis aries
Formamidine acetate
-
 Bos taurus
Formamidine acetate
-
 Cavia porcellus
Formamidine acetate
-
 Ovis aries
Hg2+
-
 Bos taurus
Hg2+
-
 Cavia porcellus
Hg2+
-
 Ovis aries
Mn2+
-
 Bos taurus
Mn2+
-
 Cavia porcellus
Mn2+
-
 Ovis aries
NEM higher concentrations Bos taurus
NEM higher concentrations Cavia porcellus
NEM higher concentrations Ovis aries
p-chloromercuribenzoate
-
 Bos taurus
p-chloromercuribenzoate
-
 Cavia porcellus
p-chloromercuribenzoate
-
 Ovis aries
SU 10603 less effective Bos taurus
SU 10603 less effective Cavia porcellus
SU 10603 less effective Ovis aries
Zn2+
-
 Bos taurus
Zn2+
-
 Cavia porcellus
Zn2+
-
 Ovis aries

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial crista
-
 Cavia porcellus 30061
-
mitochondrial crista
-
 Bos taurus 30061
-
mitochondrial crista
-
 Ovis aries 30061
-
mitochondrial membrane
-
 Cavia porcellus 31966
-
mitochondrial membrane
-
 Bos taurus 31966
-
mitochondrial membrane
-
 Ovis aries 31966
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ increase of activity, Na+, K+ alone or together are ineffective Cavia porcellus
Ca2+ increase of activity, Na+, K+ alone or together are ineffective Bos taurus
Ca2+ increase of activity, Na+, K+ alone or together are ineffective Ovis aries

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
corticosterone + reduced adrenal ferredoxin + O2 Cavia porcellus reaction in the biosynthesis of aldosterone 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
-
 ?
corticosterone + reduced adrenal ferredoxin + O2 Bos taurus reaction in the biosynthesis of aldosterone 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
-
 ?
corticosterone + reduced adrenal ferredoxin + O2 Ovis aries reaction in the biosynthesis of aldosterone 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Cavia porcellus
-
-
-
Ovis aries
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex
-
 Cavia porcellus
-
adrenal cortex
-
 Bos taurus
-
adrenal cortex
-
 Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
corticosterone + reduced adrenal ferredoxin + O2
-
 Cavia porcellus 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
-
 ?
corticosterone + reduced adrenal ferredoxin + O2
-
 Bos taurus 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
-
 ?
corticosterone + reduced adrenal ferredoxin + O2
-
 Ovis aries 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
-
 ?
corticosterone + reduced adrenal ferredoxin + O2 reaction in the biosynthesis of aldosterone Cavia porcellus 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
-
 ?
corticosterone + reduced adrenal ferredoxin + O2 reaction in the biosynthesis of aldosterone Bos taurus 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
-
 ?
corticosterone + reduced adrenal ferredoxin + O2 reaction in the biosynthesis of aldosterone Ovis aries 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Cavia porcellus
37
-
 assay at Bos taurus
37
-
 assay at Ovis aries

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3
-
 assay at Cavia porcellus
7.3
-
 assay at Bos taurus
7.3
-
 assay at Ovis aries

Cofactor

Cofactor Comment Organism Structure
NADPH activation, no activation by NADH, FAD, FMN, cytochrome c, GSH, dehydroascorbate, in vitro best stimulation by NADPH-regenerating system instead of exogenous NADPH Cavia porcellus
NADPH activation, no activation by NADH, FAD, FMN, cytochrome c, GSH, dehydroascorbate, in vitro best stimulation by NADPH-regenerating system instead of exogenous NADPH Bos taurus
NADPH activation, no activation by NADH, FAD, FMN, cytochrome c, GSH, dehydroascorbate, in vitro best stimulation by NADPH-regenerating system instead of exogenous NADPH Ovis aries
reduced adrenal ferredoxin
-
 Cavia porcellus
reduced adrenal ferredoxin
-
 Bos taurus
reduced adrenal ferredoxin
-
 Ovis aries