Literature summary for 1.14.15.6 extracted from

Evans, A.; Nunez, B.
Regulation of mRNAs encoding the steroidogenic acute regulatory protein and cholesterol side-chain cleavage enzyme in the elasmobranch interrenal gland (2010), Gen. Comp. Endocrinol., 168, 121-132.

Search for more literature for 1.14.15.6

Cloned(Commentary)

Cloned (Comment)	Organism
DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, and expression in COS-1 cells with adrenodoxin resulting in significantly more pregnenolone, co-expression with the steroidogenic acute regulatory protein and a human P450scc/adrenodoxin reductase/adrenodoxin fusion constructs. COS-1 cells transfected with a modified construct in which human P450scc is replaced by Dasyatis sabina P450scc show higher rates than cells transfected with Dasyatis sabina P450scc alone. Suncloning in Escherichia coli strain DH5alpha	Hypanus sabinus

Cloned (Comment)

Organism

DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, and expression in COS-1 cells with adrenodoxin resulting in significantly more pregnenolone, co-expression with the steroidogenic acute regulatory protein and a human P450scc/adrenodoxin reductase/adrenodoxin fusion constructs. COS-1 cells transfected with a modified construct in which human P450scc is replaced by Dasyatis sabina P450scc show higher rates than cells transfected with Dasyatis sabina P450scc alone. Suncloning in Escherichia coli strain DH5alpha

Hypanus sabinus

Organism

Organism	UniProt	Comment	Textmining
Hypanus sabinus	D0EFX3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
interrenal gland	-	Hypanus sabinus	-

Synonyms

Synonyms	Comment	Organism
cytochrome P450 cholesterol side chain cleavage	-	Hypanus sabinus
P450scc	-	Hypanus sabinus

General Information

General Information	Comment	Organism
physiological function	the enzyme shows steroidogenic activity. The stress peptide adrenocorticotropic hormone, ACTH, elicits its effects on corticosteroidogenesis in part through regulation of StAR and P450scc mRNAs. Chronic ACTH-induced glucocorticoid synthesis in elasmobranchs is mediated by regulation of primary steroidogenic mRNAs	Hypanus sabinus

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Release 2023.1 (January 2023)