Literature summary for 1.14.15.6 extracted from

Zhang, X.; Liu, Y.; Wang, Y.
The influence of the adjacent hydrogen bond on the hydroxylation processes mediated by cytochrome P450 side-chain cleavage enzyme (2014), Theoret. Chem. Accounts, 133, 1-8 .

No PubMed abstract available

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Crystallization (Commentary)

Crystallization (Comment)	Organism
dispersion-corrected density functional theoretical calculations. The hydrogen bond effect of a water molecule within the active site lowers the energy barrier significantly. The adjacent hydrogen bond between the hydroxyl group of the substrate and the oxo group of compound I in the second hydroxylation affects the H-abstraction significantly and also affects the transition state by bending the alignment of the C-H-O moiety. The reactions proceed via a typical two-state reactivity mechanism	synthetic construct

Crystallization (Comment)

Organism

dispersion-corrected density functional theoretical calculations. The hydrogen bond effect of a water molecule within the active site lowers the energy barrier significantly. The adjacent hydrogen bond between the hydroxyl group of the substrate and the oxo group of compound I in the second hydroxylation affects the H-abstraction significantly and also affects the transition state by bending the alignment of the C-H-O moiety. The reactions proceed via a typical two-state reactivity mechanism

synthetic construct

Organism

Organism	UniProt	Comment	Textmining
synthetic construct	-	-	-

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Release 2023.1 (January 2023)