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Literature summary for 1.14.16.1 extracted from

  • Boonyapiwat, B.; Panaretou, B.; Forbes, B.; Mitchell, S.C.; Steventon, G.B.
    Human phenylalanine monooxygenase and thioether metabolism (2009), J. Pharm. Pharmacol., 61, 63-67.
    View publication on PubMed
Search for more literature for 1.14.16.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli TB1 cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1
-
 L-phenylalanine wild type enzyme, in 50 mM potassium phosphate buffer, pH 6.8, at 37°C Homo sapiens
8.3
-
 (S)-carboxymethyl-L-cysteine wild type enzyme, in 50 mM potassium phosphate buffer, pH 6.8, at 37°C Homo sapiens
20.3
-
 (S)-methyl-L-cysteine wild type enzyme, in 50 mM potassium phosphate buffer, pH 6.8, at 37°C Homo sapiens
29.8
-
 N-acetyl-(S)-carboxymethyl-L-cysteine wild type enzyme, in 50 mM potassium phosphate buffer, pH 6.8, at 37°C Homo sapiens
32.1
-
 N-acetyl-(S)-methyl-L-cysteine wild type enzyme, in 50 mM potassium phosphate buffer, pH 6.8, at 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P00439
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-butyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2 low activity Homo sapiens ?
-
 ?
(S)-carboxymethyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2 low activity Homo sapiens (S)-carboxymethyl-L-cysteine S-oxide + dihydrobiopterin + H2O
-
 ?
(S)-ethyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2
-
 Homo sapiens (S)-ethyl-L-cysteine S-oxide + dihydrobiopterin + H2O
-
 ?
(S)-ethyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2 low activity Homo sapiens ?
-
 ?
(S)-methyl-ergothionine + 5,6,7,8-tetrahydrobiopterin + O2 low activity Homo sapiens ?
-
 ?
(S)-methyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2 low activity Homo sapiens (S)-methyl-L-cysteine S-oxide + dihydrobiopterin + H2O
-
 ?
(S)-propyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2 low activity Homo sapiens ?
-
 ?
L-methionine + 5,6,7,8-tetrahydrobiopterin + O2 low activity Homo sapiens ?
-
 ?
L-phenylalanine + 5,6,7,8-tetrahydrobiopterin + O2 highest activity Homo sapiens L-tyrosine + 4a-hydroxytetrahydrobiopterin
-
 ?
additional information thiodiglycolic acid, (S)-pentyl-L-cysteine, (S)-hexyl-L-cysteine, (S)-heptyl-L-cysteine, (S)-octyl-L-cysteine, and (S)-benzyl-L-cysteine are no substrates Homo sapiens ?
-
 ?
N-acetyl-(S)-carboxymethyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2
-
 Homo sapiens ?
-
 ?
N-acetyl-(S)-methyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
tetramer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
PAH
-
 Homo sapiens
phenylalanine monooxygenase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
5,6,7,8-tetrahydro-L-biopterin
-
 Homo sapiens