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Literature summary for 1.14.16.1 extracted from

  • Zhang, S.; Hinck, A.P.; Fitzpatrick, P.F.
    The amino acid specificity for activation of phenylalanine hydroxylase matches the specificity for stabilization of regulatory domain dimers (2015), Biochemistry, 54, 5167-5174 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.16.1

Activating Compound

Activating Compound Comment Organism Structure
(S)-2-amino-3-phenyl-1-propanol 6.5fold activation at 10 mM Rattus norvegicus
3-Phenylpropionate 1.8fold activation at 50 mM Rattus norvegicus
D-phenylalanine 7.1fold activation at 10 mM Rattus norvegicus
L-4-aminophenylalanine 3.2fold activation at 10 mM Rattus norvegicus
L-isoleucine 1.5fold activation at 50 mM Rattus norvegicus
L-leucine 2.2fold activation at 50 mM Rattus norvegicus
L-methionine 5.8fold activation at 50 mM Rattus norvegicus
L-norleucine 6.6fold activation at 50 mM Rattus norvegicus
L-phenylalanine 6fold activation at 1 mM Rattus norvegicus
additional information not significantly activated by L-valine, L-alanine, and L-serine Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-phenylalanine + tetrahydrobiopterin + O2 Rattus norvegicus
-
 L-tyrosine + 4a-hydroxytetrahydrobiopterin
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P04176
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-phenylalanine + tetrahydrobiopterin + O2
-
 Rattus norvegicus L-tyrosine + 4a-hydroxytetrahydrobiopterin
-
 ?

Synonyms

Synonyms Comment Organism
PheH
-
 Rattus norvegicus
phenylalanine hydroxylase
-
 Rattus norvegicus