Literature summary for 1.14.16.1 extracted from

Arturo, E.; Gupta, K.; Héroux, A.; Stith, L.; Cross, P.; Parker, E.; Loll, P.; Jaffe, E.
First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer (2016), Proc. Natl. Acad. Sci. USA, 113, 2394-2399 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BLR-DE3 cells	Rattus norvegicus

Crystallization (Commentary)

Crystallization (Comment)	Organism
vapor diffusion method, using 140 mM Na-acetate, 70 mM Na-citrate, 100 mM Na-cacodylate (pH 6.5), and 31.5% (w/v) PEG 1000	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-phenylalanine + tetrahydrobiopterin + O2	Rattus norvegicus	-	L-tyrosine + 4a-hydroxytetrahydrobiopterin	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P04176	-	-

Purification (Commentary)

Purification (Comment)	Organism
phenyl Sepharose column chromatography and HiTrap Q column chromatography	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-phenylalanine + tetrahydrobiopterin + O2	-	Rattus norvegicus	L-tyrosine + 4a-hydroxytetrahydrobiopterin	-	?

Subunits

Subunits	Comment	Organism
homotetramer	x-ray crystallography	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
PAH	-	Rattus norvegicus
phenylalanine hydroxylase	-	Rattus norvegicus

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Release 2023.1 (January 2023)