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Literature summary for 1.14.16.2 extracted from
- Tyrosine hydroxylase.The initial step in norepinephrine biosynthesis (1964), J. Biol. Chem., 239, 2910-2917.
General Stability
| General Stability | Organism |
|---|---|
| 0.1 M 2-mercaptoethanol is necessary for stabilization during purification | Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,2'-dipyridyl | - |
Bos taurus |  |
| 2-methyl-L-tyrosine | - |
Bos taurus | |
| 3,4-dihydroxybenzoic acid | - |
Bos taurus | |
| alpha-Propyldihydroxyphenylacetamide | - |
Bos taurus | |
| dopamine | - |
Bos taurus | |
| L-Dopa | - |
Bos taurus | |
| norepinephrine | - |
Bos taurus | |
| phenylalanine | L-isomer, not D-isomer | Bos taurus | |
| phenylalanine | - |
Cavia porcellus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Bos taurus | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Iron | Fe2+ activates | Bos taurus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tyrosine + tetrahydrobiopterin + O2 | Cavia porcellus | - |
3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | - |
? | |
| L-tyrosine + tetrahydrobiopterin + O2 | Bos taurus | first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Cavia porcellus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal medulla | - |
Bos taurus | - |
| brain | - |
Bos taurus | - |
| nervous system | sympathetic, innervated | Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tyrosine + 2-amino-4-hydroxy-6,7-dimethyltetrahydropterin + O2 | - |
Bos taurus | ? | - |
? | |
| L-tyrosine + tetrahydrobiopterin + O2 | - |
Cavia porcellus | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | - |
? | |
| L-tyrosine + tetrahydrobiopterin + O2 | - |
Cavia porcellus | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | 3,4-dihydroxy-L-phenylalanine is identical with dopa | ? | |
| L-tyrosine + tetrahydrobiopterin + O2 | - |
Bos taurus | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | 3,4-dihydroxy-L-phenylalanine is identical with dopa | ? | |
| L-tyrosine + tetrahydrobiopterin + O2 | first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine | Bos taurus | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | - |
? | |
| L-tyrosine + tetrahydrofolic acid + O2 | - |
Bos taurus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.2 | - |
- |
Bos taurus |
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Release 2023.1 (January 2023)
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