Literature summary for 1.14.18.1 extracted from

Ryu, Y.B.; Ha, T.J.; Curtis-Long, M.J.; Ryu, H.W.; Gal, S.W.; Park, K.H.
Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz (2008), J. Enzyme Inhib. Med. Chem., 23, 922-930.

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Inhibitors

Inhibitors	Comment	Organism	Structure
cyclomorusin	exhibits competitive inhibition characteristics. Flavone displaying tyrosinase inhibitory activity, isolated from the stem barks of Morus lhou. Inhibitory potency of this flavonoid toward monophenolase activity of mushroom tyrosinase is investigated	Agaricus bisporus
kuwanon C	exhibits competitive inhibition characteristics. Flavone displaying tyrosinase inhibitory activity, isolated from the stem barks of Morus lhou. Inhibitory potency of this flavonoid toward monophenolase activity of mushroom tyrosinase is investigated	Agaricus bisporus
mormin	exhibits competitive inhibition characteristics. Characterized as a new flavone possesing a 3-hydroxymethyl-2-butenyl at C-3. Flavone displaying tyrosinase inhibitory activity, isolated from the stem barks of Morus lhou. Inhibitory potency of this flavonoid toward monophenolase activity of mushroom tyrosinase is investigated	Agaricus bisporus
morusin	Flavone displaying tyrosinase inhibitory activity, isolated from the stem barks of Morus lhou. Inhibitory potency of this flavonoid toward monophenolase activity of mushroom tyrosinase is investigated	Agaricus bisporus
norartocarpetin	exhibits competitive inhibition characteristics. Flavone displaying tyrosinase inhibitory activity, isolated from the stem barks of Morus lhou. Inhibitory potency of this flavonoid toward monophenolase activity of mushroom tyrosinase is investigated. Norartocarpetin shows a time-dependent inhibition against oxidation of l-tyrosine. It also operated under the enzyme isomerization model	Agaricus bisporus

Organism

Organism	UniProt	Comment	Textmining
Agaricus bisporus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
monophenolase	-	Agaricus bisporus
tyrosinase	-	Agaricus bisporus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0012	-	for monophenolase activity	Agaricus bisporus	norartocarpetin
0.088	-	for monophenolase activity	Agaricus bisporus	mormin
0.092	-	for monophenolase activity	Agaricus bisporus	cyclomorusin
0.135	-	for monophenolase activity	Agaricus bisporus	kuwanon C
0.25	-	for monophenolase activity	Agaricus bisporus	morusin

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Release 2023.1 (January 2023)