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Literature summary for 1.14.18.1 extracted from

  • Kang, S.S.; Kim, H.J.; Jin, C.; Lee, Y.S.
    Synthesis of tyrosinase inhibitory (4-oxo-4H-pyran-2-yl)acrylic acid ester derivatives (2009), Bioorg. Med. Chem. Lett., 19, 188-191.
    View publication on PubMed
Search for more literature for 1.14.18.1

Inhibitors

Inhibitors Comment Organism Structure
1-methylethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
-
 Agaricus bisporus
2-(2-hydroxyethoxy)ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
-
 Agaricus bisporus
2-(2-methoxyethoxy)ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
-
 Agaricus bisporus
2-hydroxyethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
-
 Agaricus bisporus
2-methoxyethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
-
 Agaricus bisporus
2-[2-(2-hydroxyethoxy)ethoxy]ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
-
 Agaricus bisporus
2-[2-(2-methoxyethoxy)ethoxy]ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
-
 Agaricus bisporus
caffeic acid
-
 Agaricus bisporus
ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
-
 Agaricus bisporus
kojic acid
-
 Agaricus bisporus
octyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
-
 Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + O2
-
 Agaricus bisporus L-DOPA + H2O
-
 ?

Synonyms

Synonyms Comment Organism
tyrosinase
-
 Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0265
-
 in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus 2-(2-hydroxyethoxy)ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
0.0363
-
 in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
0.0591
-
 in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus 2-(2-methoxyethoxy)ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
0.0676
-
 in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus 2-[2-(2-methoxyethoxy)ethoxy]ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
0.0749
-
 in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus 2-hydroxyethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
0.0792
-
 in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus 2-[2-(2-hydroxyethoxy)ethoxy]ethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
0.0803
-
 in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus 1-methylethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
0.0981
-
 in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus 2-methoxyethyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate
0.323
-
 in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus kojic acid
0.4
-
 in 0.1 M phosphate buffer (pH 6.8), at 37°C Agaricus bisporus octyl (2E)-3-(5-hydroxy-4-oxo-4H-pyran-2-yl)prop-2-enoate