Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-hydroxybenzaldehyde | 16.4% inhibition at 0.2 mM | Agaricus bisporus | |
4-methoxycinnamic acid | 46.62% inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(2-(2-methoxyethoxy)ethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | 97.49% inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(2-(2-methoxyethoxy)ethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)trione | 14.3% inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(2-(2-methoxyethoxy)ethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | complete inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(2-(2-methoxyethoxy)ethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione | 88.67% inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(2-butoxyethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | 78.67% inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(2-butoxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | 85.88% inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(2-butoxyethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione | complete inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(2-hydroxyethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | 95.86% inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(2-hydroxyethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione | 5.27% inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(2-hydroxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | 16.54% inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(2-hydroxyethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione | 22.41% inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(2-methoxyethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | complete inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(2-methoxyethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione | 23.12% inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(2-methoxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | complete inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(2-methoxyethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione | complete inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(4-methoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione | 12.2% inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(4-methoxybutoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | 9.85% inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(4-methoxyethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione | 1.15% inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-(4-methoxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | complete inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-hydroxybenzyl)-2-thioxo-dihydropyrimidine-4,6(1H,5H)-dione | complete inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-hydroxybenzyl)pyrimidine-2,4,6(1H,3H,5H)-trione | 47.5% inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-hydroxybenzylidene)-2-thioxo-dihydropyrimidine-4,6(1H,5H)-dione | complete inhibition at 0.2 mM | Agaricus bisporus | |
5-(4-hydroxybenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione | complete inhibition at 0.2 mM | Agaricus bisporus | |
Barbituric acid | 5.95% inhibition at 0.2 mM | Agaricus bisporus | |
additional information | 5-(4-(2-butoxyethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione is not active against tyrosinase | Agaricus bisporus | |
Thiobarbituric acid | 8.21% inhibition at 0.2 mM | Agaricus bisporus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agaricus bisporus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-DOPA + O2 | - |
Agaricus bisporus | dopaquinone + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosinase | - |
Agaricus bisporus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.01398 | - |
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-hydroxybenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione | |
0.01449 | - |
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-hydroxybenzylidene)-2-thioxo-dihydropyrimidine-4,6(1H,5H)-dione | |
0.02843 | - |
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(2-methoxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | |
0.0342 | - |
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(2-(2-methoxyethoxy)ethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | |
0.04545 | - |
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(2-butoxyethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione | |
0.07002 | - |
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-hydroxybenzyl)-2-thioxo-dihydropyrimidine-4,6(1H,5H)-dione | |
0.07542 | - |
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(2-methoxyethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione | |
0.0778 | - |
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(4-methoxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | |
0.1074 | - |
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(2-butoxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | |
0.1128 | - |
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(2-methoxyethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | |
0.1325 | - |
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(2-(2-methoxyethoxy)ethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | |
0.1374 | - |
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(2-(2-methoxyethoxy)ethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione | |
0.1559 | - |
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(2-hydroxyethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | |
0.1793 | - |
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(2-butoxyethoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | |
0.2 | - |
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(2-hydroxyethoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione | |
0.2 | - |
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(4-methoxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione | |
0.2 | - |
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(2-hydroxyethoxy)benzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | |
0.2 | - |
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-hydroxybenzyl)pyrimidine-2,4,6(1H,3H,5H)-trione | |
0.2 | - |
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(2-hydroxyethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione | |
0.2 | - |
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(2-methoxyethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione | |
0.2 | - |
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(2-(2-methoxyethoxy)ethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)trione | |
0.2 | - |
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(4-methoxyethoxy)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione | |
0.2 | - |
IC50 above 0.2 mM, in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 5-(4-(4-methoxybutoxy)benzyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | |
1.22 | - |
in 50 mM Na2HPO4-NaH2PO4 buffer (pH 6.8), at 25°C | Agaricus bisporus | 4-hydroxybenzaldehyde |