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Literature summary for 1.14.18.1 extracted from

  • Antonella Fai, A.F.; Corda, M.; Era, B.; Fadda, M.; Matos, M.; Quezada, E.; Santana, L.; Picciau, C.; Podda, G.; Delogu, G.
    Tyrosinase inhibitor activity of coumarin-resveratrol hybrids (2009), Molecules, 14, 2514-2520.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.18.1

Inhibitors

Inhibitors Comment Organism Structure
3-(3',4',5'-trihydroxyphenyl)-6,8-dihydroxycoumarin potent, non-competitive tyrosinase inhibitor, 68.3% inhibition at 0.8 mM Agaricus bisporus
3-(3-hydroxyphenyl)-2H-chromen-2-one 19.3% inhibition at 0.8 mM Agaricus bisporus
6-hydroxy-3-(4'-hydroxyphenyl)coumarin 26.7% inhibition at 0.8 mM Agaricus bisporus
7-hydroxy-3-(4-hydroxyphenyl)-2H-chromen-2-one 9.6% inhibition at 0.8 mM Agaricus bisporus
umbelliferone
-
 Agaricus bisporus

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-DOPA + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?

Synonyms

Synonyms Comment Organism
tyrosinase
-
 Agaricus bisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.1
-
 IC50 above 0.1 mM, in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C Agaricus bisporus 7-hydroxy-3-(4-hydroxyphenyl)-2H-chromen-2-one
0.27
-
 in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C Agaricus bisporus 3-(3',4',5'-trihydroxyphenyl)-6,8-dihydroxycoumarin
0.42
-
 in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C Agaricus bisporus umbelliferone
1.567
-
 in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C Agaricus bisporus 6-hydroxy-3-(4'-hydroxyphenyl)coumarin
3.68
-
 in 0.067 M phosphoric acid buffer (pH 6.8), at 25°C Agaricus bisporus 3-(3-hydroxyphenyl)-2H-chromen-2-one