Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.18.1 extracted from

  • Ortiz-Ruiz, C.V.; Maria-Solano, M.A.; Garcia-Molina, M.d.e.l. .M.; Varon, R.; Tudela, J.; Tomas, V.; Garcia-Canovas, F.
    Kinetic characterization of substrate-analogous inhibitors of tyrosinase (2015), IUBMB Life, 67, 757-767 .
    View publication on PubMed
Search for more literature for 1.14.18.1

Inhibitors

Inhibitors Comment Organism Structure
2,4-dichlorocinnamic acid
-
 Agaricus bisporus
2-chlorocinnamic acid
-
 Agaricus bisporus
2-cyano-4-hydroxycinnamic acid
-
 Agaricus bisporus
4-Aminobenzoic acid a noncompetitive inhibitor Agaricus bisporus
benzoic acid competitive inhibition, 45% inhibition of diphenolase activity at 0.7 mM, 42% inhibition of monophenolase activity at 0.7 mM Agaricus bisporus
Cinnamic acid competitive inhibition, 48% inhibition of diphenolase activity at 1.0 mM, 50% inhibition of monophenolase activity at 1.0 mM Agaricus bisporus
additional information inhibition mechanism of mono- and diphenolase activities, overview Agaricus bisporus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Michaelis-Menten kinetics Agaricus bisporus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ a copper-containing enzyme Agaricus bisporus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 L-dopa + O2 Agaricus bisporus
-
 2 dopaquinone + 2 H2O
-
 ?
tyrosine + O2 Agaricus bisporus
-
 dopaquinone + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
L-tyrosine + O2 = dopaquinone + H2O reaction mechanism with mono- and diphenols, overview Agaricus bisporus
a

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Agaricus bisporus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 2-methyl-L-dopa + O2
-
 Agaricus bisporus 2 2-methyldopaquinone + 2 H2O
-
 ?
2 L-dopa + O2
-
 Agaricus bisporus 2 dopaquinone + 2 H2O
-
 ?
2-methyl-L-tyrosine + O2
-
 Agaricus bisporus 2-methyldopaquinone + H2O
-
 ?
L-tyrosine + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?
tyrosine + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?

Synonyms

Synonyms Comment Organism
mushroom tyrosinase
-
 Agaricus bisporus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics of mono- and diphenolase activities, detailed overview Agaricus bisporus
0.44 0.59 Cinnamic acid versus different substrates, pH and temperature not specified in the publication Agaricus bisporus
0.53 0.6 benzoic acid versus different substrates, pH and temperature not specified in the publication Agaricus bisporus