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Literature summary for 1.14.18.9 extracted from
- Mechanism-based inactivation of 4-methylsterol oxidase by 4alpha-(cyanomethyl)-5alpha-cholestan-3beta-ol (1982), J. Am. Chem. Soc., 104, 4729-4730 .
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4alpha-(cyanomethyl)-5alpha-cholestan-3beta-ol | competitive inhibitor | Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.125 | - |
4alpha-methyl-5alpha-cholestan-3beta-ol | at pH 7.4 and 37°C | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4alpha-methyl-5alpha-cholestan-3beta-ol + reduced acceptor | - |
Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 4-methylsterol oxidase | - |
Rattus norvegicus |
| NAD(P)H-dependent methylsterol oxidase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | required | Rattus norvegicus | |
| NADPH | required | Rattus norvegicus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.18 | - |
4alpha-(cyanomethyl)-5alpha-cholestan-3beta-ol | at pH 7.4 and 37°C | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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