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Literature summary for 1.14.19.1 extracted from

  • Iwai, T.; Kume, S.; Chin-Kanasaki, M.; Kuwagata, S.; Araki, H.; Takeda, N.; Sugaya, T.; Uzu, T.; Maegawa, H.; Araki, S.I.
    Stearoyl-CoA desaturase-1 protects cells against lipotoxicity-mediated apoptosis in proximal tubular cells (2016), Int. J. Mol. Sci., 17, E1868 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.19.1

Application

Application Comment Organism
pharmacology enhancing SCD1-mediated desaturation of saturated fatty acids and subsequent formation of neutral lipid droplets may become a promising therapeutic target to reduce saturated fatty acid-induced lipotoxicity in the pathogenesis of diabetic nephropathy Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information siRNA-mediated downregulation of stearoyl-coenzyme A desaturase-1 (SCD1) in diabetic proximal tubular epithelial cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Mus musculus
-
 oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P13516
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Mus musculus
-
renal proximal tubule
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Mus musculus oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?

Synonyms

Synonyms Comment Organism
SCD1
-
 Mus musculus
stearoyl-CoA desaturase-1
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
 Mus musculus

General Information

General Information Comment Organism
malfunction siRNA against SCD1 exacerbates the apoptosis Mus musculus
metabolism the enzyme is involved in the metabolism of free fatty acids Mus musculus
additional information stearoyl-CoA desaturase-1 (SCD1) expression level significantly decreases in the kidneys of high-fat diet (HFD)-induced diabetic mice, compared with non-diabetic mice Mus musculus
physiological function stearoyl-CoA desaturase-1, SCD1, is an enzyme that desaturates satruated fatty acids (SFA), converting them to monounsaturated fatty acids (MUFAs), leading to the formation of neutral lipid droplets. SCD1 activity protects cells against lipotoxicity-mediated apoptosis in proximal tubular cells. In culture, retrovirus-mediated overexpression of SCD1 or MUFA treatment significantly ameliorates saturated fatty acid-induced apoptosis in proximal tubular epithelial cells by enhancing intracellular lipid droplet formation. Both overexpression of SCD1 and monounsaturated fatty acid treatment reduces SFA-induced apoptosis via reducing endoplasmic reticulum stress in cultured proximal tubular epithelial cells Mus musculus