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Literature summary for 1.14.19.17 extracted from

  • Ezanno, H.; Le Bloch, J.; Beauchamp, E.; Lagadic-Gossmann, D.; Legrand, P.; Rioux, V.
    Myristic acid increases dihydroceramide DELTA4-desaturase 1 (DES1) activity in cultured rat hepatocytes (2012), Lipids, 47, 117-128.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
myristic acid myristic acid significantly increases DES1 activity in the mitochondria of cultured rat hepatocytes Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
alpha-linolenic acid
-
Rattus norvegicus
linoleic acid
-
Rattus norvegicus
palmitic acid
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00148
-
N-octanoyldihydroceramide at pH 7.4 and 37°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Rattus norvegicus 5783
-
mitochondrion
-
Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q564G3
-
-

Purification (Commentary)

Purification (Comment) Organism
HisTrap column chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-octanoyldihydroceramide + NAD(P)H + O2 + H+
-
Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
DES1 isoform Rattus norvegicus
dihydroceramide DELTA4-desaturase 1
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADH
-
Rattus norvegicus
NADPH
-
Rattus norvegicus