Application | Comment | Organism |
---|---|---|
synthesis | Oenothera biennis is grown commercially for gamma-linolenic acid production by the fatty acid DELTA6-desaturase enzymatic reaction | Oenothera biennis |
Cloned (Comment) | Organism |
---|---|
gene ObD6Des, DNA and amino acid sequence determination and analysis, sequence comparisons, functional expression in Saccharomyces cerevisiae strain W303-a | Oenothera biennis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-linoleoyl-CoA + AH2 + O2 | Oenothera biennis | - |
stearidonoyl-CoA + A + 2 H2O | - |
? | |
linoleoyl-CoA + AH2 + O2 | Oenothera biennis | - |
gamma-linolenoyl-CoA + A + 2 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oenothera biennis | E1U2Q3 | gene ObD6Des | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-linoleoyl-CoA + AH2 + O2 | - |
Oenothera biennis | stearidonoyl-CoA + A + 2 H2O | - |
? | |
linoleoyl-CoA + AH2 + O2 | - |
Oenothera biennis | gamma-linolenoyl-CoA + A + 2 H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the enzyme sequence comprises the characteristics of membrane-bound desaturases, including three conserved histidine-rich motifs, hydropathy profile, and a cytochrome b5 domain at the N-terminus, overview | Oenothera biennis |
Synonyms | Comment | Organism |
---|---|---|
D6Des | - |
Oenothera biennis |
fatty acid DELTA6-desaturase | - |
Oenothera biennis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome b5 | binds at the N-terminus of the enzyme | Oenothera biennis |
General Information | Comment | Organism |
---|---|---|
physiological function | fatty acid DELTA6-desaturase is the essential enzyme for polyunsaturated fatty acids biosynthesis and is responsible for the first step by converting linoleic acid to gamma-linolenoyl-CoA, and alpha-linolenic acid to stearidonic acid | Oenothera biennis |