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Literature summary for 1.14.19.47 extracted from

  • Wang, Y.D.; Peng, K.C.; Wu, J.L.; Chen, J.Y.
    Transgenic expression of salmon DELTA-5 and DELTA-6 desaturase in zebrafish muscle inhibits the growth of Vibrio alginolyticus and affects fish immunomodulatory activity (2014), Fish Shellfish Immunol., 39, 223-230 .
    View publication on PubMed

Application

Application Comment Organism
agriculture DELTA-5 and DELTA-6 desaturase are candidate genes for use in aquaculture, to enhance both disease resistance and fish oil production Salmo salar

Cloned(Commentary)

Cloned (Comment) Organism
investigation of the effects of these proteins on antibacterial and immunomodulatory activity in transgenic zebrafish infected with Vibrio alginolyticus. Overexpression of DELTA-5 and DELTA-6 desaturase enhances antibacterial activity at 4 and 12 h after injection of bacteria into muscle, as compared to controls. Expression of immune-related genes (IL-1b, IL-22, and TNF-a) is observed to be altered in transgenic fish after 4 h of bacterial infection, resulting in a significant decrease in the inflammatory response, as compared to control fish. Muscle-specific expression of transgenic desaturases in zebrafish not only enhance polyunsaturated fatty acid production, but also enhances antibacterial and anti-inflammatory activity Salmo salar

Organism

Organism UniProt Comment Textmining
Salmo salar Q6SES0
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-

Synonyms

Synonyms Comment Organism
D-6 desaturase
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Salmo salar
DELTA-6 desaturase
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Salmo salar

General Information

General Information Comment Organism
physiological function investigation of the effects of these proteins on antibacterial and immunomodulatory activity in transgenic zebrafish infected with Vibrio alginolyticus. Overexpression of DELTA-5 and DELTA-6 desaturase enhances antibacterial activity at 4 and 12 h after injection of bacteria into muscle, as compared to controls. Expression of immune-related genes (IL-1b, IL-22, and TNF-a) is observed to be altered in transgenic fish after 4 h of bacterial infection, resulting in a significant decrease in the inflammatory response, as compared to control fish. Muscle-specific expression of transgenic desaturases in zebrafish not only enhance polyunsaturated fatty acid production, but also enhances antibacterial and anti-inflammatory activity Salmo salar