Application | Comment | Organism |
---|---|---|
pharmacology | 5-Br- and 5-Cl-tryptophan could presumably be applied as a pharmacologically attractive precursor of serotonin | Streptomyces rugosporus |
Cloned (Comment) | Organism |
---|---|
for expression in Pseudomonas fluorescens | Streptomyces rugosporus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + FADH2 + Br- + O2 + H+ | Streptomyces rugosporus | - |
5-bromo-L-tryptophan + FAD + 2 H2O | - |
? | |
L-tryptophan + FADH2 + Cl- + O2 + H+ | Streptomyces rugosporus | - |
5-chloro-L-tryptophan + FAD + 2 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces rugosporus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
using a nickel-chelating HisTrap HP column | Streptomyces rugosporus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + FADH2 + Br- + O2 + H+ | - |
Streptomyces rugosporus | 5-bromo-L-tryptophan + FAD + 2 H2O | - |
? | |
L-tryptophan + FADH2 + Cl- + O2 + H+ | - |
Streptomyces rugosporus | 5-chloro-L-tryptophan + FAD + 2 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
halogenase | - |
Streptomyces rugosporus |
trp-5-halogenase | - |
Streptomyces rugosporus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
enzyme assay | Streptomyces rugosporus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
enzyme assay | Streptomyces rugosporus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FADH2 | - |
Streptomyces rugosporus |