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Literature summary for 1.14.19.64 extracted from

  • Yahyazadeh, M.; Ratmoyo, P.; Bittner, F.; Sato, F.; Selmar, D.
    Cloning and characterization of Cheilanthifoline and stylopine synthase genes from Chelidonium majus (2017), Plant Cell Physiol., 58, 1421-1430 .
No PubMed abstract available
Search for more literature for 1.14.19.64

Cloned(Commentary)

Cloned (Comment) Organism
heterologously expressed in Saccharomyces cerevisiae Chelidonium majus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-cheilanthifoline + [reduced NADPH-hemoprotein reductase] + O2 Chelidonium majus the enzyme is involved in biosynthesis of stylopine (S)-stylopine + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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 ?

Organism

Organism UniProt Comment Textmining
Chelidonium majus A0A240FWB4
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-

Source Tissue

Source Tissue Comment Organism Textmining
leaf expression is very similar in both roots and leaves, although the alkaloid accumulation patterns in these organs are quite different Chelidonium majus
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root expression is very similar in both roots and leaves, although the alkaloid accumulation patterns in these organs are quite different Chelidonium majus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-cheilanthifoline + [reduced NADPH-hemoprotein reductase] + O2 the enzyme is involved in biosynthesis of stylopine Chelidonium majus (S)-stylopine + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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 ?
(S)-cheilanthifoline + [reduced NADPH-hemoprotein reductase] + O2 high substrate specificity. The only alternative substrate identified is scoulerine, which is converted by stylopine synthase to yield minor amounts of nandinine Chelidonium majus (S)-stylopine + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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 ?
(S)-scoulerine + [reduced NADPH-hemoprotein reductase] + O2
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 Chelidonium majus nandinine + [oxidized NADPH-hemoprotein reductase] + 2 H2O
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 ?

Synonyms

Synonyms Comment Organism
stylopine synthase
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 Chelidonium majus

Cofactor

Cofactor Comment Organism Structure
NADPH-hemoprotein reductase
-
 Chelidonium majus

General Information

General Information Comment Organism
metabolism the enzyme is involved in biosynthesis of stylopine Chelidonium majus