BRENDA - Enzyme Database show
show all sequences of 1.14.19.67

Morphine biosynthesis in opium poppy involves two cell types: sieve elements and laticifers

Onoyovwe, A.; Hagel, J.M.; Chen, X.; Khan, M.F.; Schriemer, D.C.; Facchini, P.J.; Plant Cell 25, 4110-4122 (2013)

Data extracted from this reference:

Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
56000
-
x * 56000, SDS-PAGE
Papaver somniferum
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(R)-reticuline + [reduced NADPH-hemoprotein reductase] + O2
Papaver somniferum
-
salutaridine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Papaver somniferum
B1NF18
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
carpel
most abundant in carpel
Papaver somniferum
-
leaf
-
Papaver somniferum
-
additional information
not detected in the latex subproteome
Papaver somniferum
-
root
-
Papaver somniferum
-
stem
most abundant in stem
Papaver somniferum
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(R)-reticuline + [reduced NADPH-hemoprotein reductase] + O2
-
728475
Papaver somniferum
salutaridine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 56000, SDS-PAGE
Papaver somniferum
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
56000
-
x * 56000, SDS-PAGE
Papaver somniferum
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(R)-reticuline + [reduced NADPH-hemoprotein reductase] + O2
Papaver somniferum
-
salutaridine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
carpel
most abundant in carpel
Papaver somniferum
-
leaf
-
Papaver somniferum
-
additional information
not detected in the latex subproteome
Papaver somniferum
-
root
-
Papaver somniferum
-
stem
most abundant in stem
Papaver somniferum
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(R)-reticuline + [reduced NADPH-hemoprotein reductase] + O2
-
728475
Papaver somniferum
salutaridine + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 56000, SDS-PAGE
Papaver somniferum
Other publictions for EC 1.14.19.67
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
743574
Fossati
Synthesis of morphinan alkalo ...
Papaver somniferum
PLoS ONE
10
e0124459
2015
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
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-
-
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1
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1
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1
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-
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-
-
-
-
-
-
-
-
-
-
-
728475
Onoyovwe
Morphine biosynthesis in opium ...
Papaver somniferum
Plant Cell
25
4110-4122
2013
-
-
-
-
-
-
-
-
-
-
1
1
-
2
-
-
-
-
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5
-
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1
1
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-
-
-
-
-
-
-
-
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-
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1
1
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5
-
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1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
720707
Wijekoon
Systematic knockdown of morphi ...
Papaver somniferum
Plant J.
69
1052-1063
2012
-
-
-
-
-
-
-
-
-
-
-
1
-
2
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2
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1
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2
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-
-
-
-
-
-
-
1
1
-
-
-
698930
Gesell
CYP719B1 is salutaridine synth ...
Papaver somniferum
J. Biol. Chem.
284
24432-24442
2009
-
-
1
-
-
-
-
1
-
-
1
1
-
4
-
-
1
-
-
-
-
-
2
-
2
-
-
1
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
1
-
-
1
1
-
-
-
1
-
-
-
-
2
-
2
-
-
1
2
-
-
-
-
-
-
-
-
-
393876
Amann
-
Purification and characterizat ...
Bos taurus, Homo sapiens, Mus musculus, Ovis aries, Rattus norvegicus, Sus scrofa
Heterocycles
1
425-440
1995
-
-
-
-
-
-
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1
9
-
1
1
-
6
-
-
1
-
-
1
-
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3
1
-
-
-
-
-
-
-
7
-
-
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-
-
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7
-
-
-
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1
9
-
1
1
-
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1
-
1
-
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3
1
-
-
-
-
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393875
Gerardy R.; Zenk
-
Formation of salutaridine from ...
Papaver somniferum
Phytochemistry
32
79-86
1993
-
-
-
-
-
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3
2
2
-
-
1
-
1
-
-
-
1
-
5
-
4
2
-
1
1
-
-
1
1
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1
-
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-
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-
1
-
-
-
-
3
-
2
2
-
-
1
-
-
-
-
-
5
-
4
2
-
1
1
-
-
1
1
-
-
-
-
-
-
-
-