BRENDA - Enzyme Database show
show all sequences of 1.14.19.71

Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus

Kato, N.; Suzuki, H.; Takagi, H.; Asami, Y.; Kakeya, H.; Uramoto, M.; Usui, T.; Takahashi, S.; Sugimoto, Y.; Osada, H.; ChemBioChem 10, 920-928 (2009)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in Saccharomyces cerevisiae
Aspergillus fumigatus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
tryprostatin A + [reduced NADPH-hemoprotein reductase] + O2
Aspergillus fumigatus
-
fumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
tryprostatin A + [reduced NADPH-hemoprotein reductase] + O2
Aspergillus fumigatus BM939
-
fumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Aspergillus fumigatus
B9WZX4
-
-
Aspergillus fumigatus BM939
B9WZX4
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
the enzyme preferably dephosphorylates disaccharides containing an O-aglycosyl linkage
722039
Aspergillus fumigatus
?
-
-
-
-
additional information
the enzyme preferably dephosphorylates disaccharides containing an O-aglycosyl linkage
722039
Aspergillus fumigatus BM939
?
-
-
-
-
tryprostatin A + [reduced NADPH-hemoprotein reductase] + O2
-
722039
Aspergillus fumigatus
fumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
tryprostatin A + [reduced NADPH-hemoprotein reductase] + O2
-
722039
Aspergillus fumigatus BM939
fumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2
-
722039
Aspergillus fumigatus
demethoxyfumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2
-
722039
Aspergillus fumigatus BM939
demethoxyfumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
heme
heme-thiolate protein (P-450)
Aspergillus fumigatus
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Saccharomyces cerevisiae
Aspergillus fumigatus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
heme
heme-thiolate protein (P-450)
Aspergillus fumigatus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
tryprostatin A + [reduced NADPH-hemoprotein reductase] + O2
Aspergillus fumigatus
-
fumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
tryprostatin A + [reduced NADPH-hemoprotein reductase] + O2
Aspergillus fumigatus BM939
-
fumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
the enzyme preferably dephosphorylates disaccharides containing an O-aglycosyl linkage
722039
Aspergillus fumigatus
?
-
-
-
-
additional information
the enzyme preferably dephosphorylates disaccharides containing an O-aglycosyl linkage
722039
Aspergillus fumigatus BM939
?
-
-
-
-
tryprostatin A + [reduced NADPH-hemoprotein reductase] + O2
-
722039
Aspergillus fumigatus
fumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
tryprostatin A + [reduced NADPH-hemoprotein reductase] + O2
-
722039
Aspergillus fumigatus BM939
fumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2
-
722039
Aspergillus fumigatus
demethoxyfumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2
-
722039
Aspergillus fumigatus BM939
demethoxyfumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
General Information
General Information
Commentary
Organism
physiological function
the enzyme is involved in the biosynthetic pathway of several indole alkaloids such as fumitremorgins and verruculogen
Aspergillus fumigatus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
the enzyme is involved in the biosynthetic pathway of several indole alkaloids such as fumitremorgins and verruculogen
Aspergillus fumigatus
Other publictions for EC 1.14.19.71
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
722039
Kato
Identification of cytochrome P ...
Aspergillus fumigatus, Aspergillus fumigatus BM939
ChemBioChem
10
920-928
2009
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