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Literature summary for 1.14.99.1 extracted from

  • Tai, H.H.; Tai, C.L.; Hollander, C.S.
    Biosynthesis of prostaglandins in rabbit kidney medulla. Properties of prostaglandin synthase (1976), Biochem. J., 154, 257-264.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
5-hydroxytryptamine stimulates Oryctolagus cuniculus
cysteine stimulates Oryctolagus cuniculus
dopamine 3,4-dihydroxyphenylethylamine, stimulates Oryctolagus cuniculus
Melatonin
-
Oryctolagus cuniculus
Oestrogens weak stimulation Oryctolagus cuniculus
quinol stimulates Oryctolagus cuniculus
reduced glutathione stimulates Oryctolagus cuniculus
Thyroid hormones weak stimulation Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline weak Oryctolagus cuniculus
2,2'-bipyridyl weak Oryctolagus cuniculus
8-hydroxyquinoline
-
Oryctolagus cuniculus
albumin bovine serum albumin inhibits by binding of arachidonic acid Oryctolagus cuniculus
azide weak Oryctolagus cuniculus
cyanide
-
Oryctolagus cuniculus
diethyldithiocarbamate
-
Oryctolagus cuniculus
EDTA weak Oryctolagus cuniculus
EGTA weak Oryctolagus cuniculus
indomethacin
-
Oryctolagus cuniculus
Meclofenamic acid
-
Oryctolagus cuniculus
p-Aminophenol
-
Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0083
-
arachidonic acid
-
Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Oryctolagus cuniculus
-
-

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney medulla Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonic acid + reduced acceptor + O2
-
Oryctolagus cuniculus prostaglandin H2 + acceptor + H2O
-
r
additional information formation of prostaglandin E2, prostaglandin F2alpha and prostaglandin D2 from arachidonic acid Oryctolagus cuniculus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8 formation of prostaglandin F2alpha Oryctolagus cuniculus
8 8.5 formation of prostaglandin E2 and D2 Oryctolagus cuniculus

pH Range

pH Minimum pH Maximum Comment Organism
6.5 9 about 70% of maximum activity at pH 6.0 and 9.0 of prostaglandin E2 formation, about 50% of maximum activity at pH 6.0 and 9.0 of prostaglandin F2alpha formation Oryctolagus cuniculus
7.2 9 about 60% of maximum activity at pH 7.2 and 9.0 of prostaglandin D2 formation Oryctolagus cuniculus