Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5-hydroxytryptamine | stimulates | Oryctolagus cuniculus | |
cysteine | stimulates | Oryctolagus cuniculus | |
dopamine | 3,4-dihydroxyphenylethylamine, stimulates | Oryctolagus cuniculus | |
Melatonin | - |
Oryctolagus cuniculus | |
Oestrogens | weak stimulation | Oryctolagus cuniculus | |
quinol | stimulates | Oryctolagus cuniculus | |
reduced glutathione | stimulates | Oryctolagus cuniculus | |
Thyroid hormones | weak stimulation | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | weak | Oryctolagus cuniculus | |
2,2'-bipyridyl | weak | Oryctolagus cuniculus | |
8-hydroxyquinoline | - |
Oryctolagus cuniculus | |
albumin | bovine serum albumin inhibits by binding of arachidonic acid | Oryctolagus cuniculus | |
azide | weak | Oryctolagus cuniculus | |
cyanide | - |
Oryctolagus cuniculus | |
diethyldithiocarbamate | - |
Oryctolagus cuniculus | |
EDTA | weak | Oryctolagus cuniculus | |
EGTA | weak | Oryctolagus cuniculus | |
indomethacin | - |
Oryctolagus cuniculus | |
Meclofenamic acid | - |
Oryctolagus cuniculus | |
p-Aminophenol | - |
Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0083 | - |
arachidonic acid | - |
Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Oryctolagus cuniculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | medulla | Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
arachidonic acid + reduced acceptor + O2 | - |
Oryctolagus cuniculus | prostaglandin H2 + acceptor + H2O | - |
r | |
additional information | formation of prostaglandin E2, prostaglandin F2alpha and prostaglandin D2 from arachidonic acid | Oryctolagus cuniculus | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8 | formation of prostaglandin F2alpha | Oryctolagus cuniculus |
8 | 8.5 | formation of prostaglandin E2 and D2 | Oryctolagus cuniculus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 9 | about 70% of maximum activity at pH 6.0 and 9.0 of prostaglandin E2 formation, about 50% of maximum activity at pH 6.0 and 9.0 of prostaglandin F2alpha formation | Oryctolagus cuniculus |
7.2 | 9 | about 60% of maximum activity at pH 7.2 and 9.0 of prostaglandin D2 formation | Oryctolagus cuniculus |