Literature summary for 1.14.99.1 extracted from

MirAfzali, Z.; Leipprandt, J.R.; McCracken, J.L.; DeWitt, D.L.
Topography of the prostaglandin endoperoxide H2 synthase-2 in membranes (2006), J. Biol. Chem., 281, 28354-28364.

Search for more literature for 1.14.99.1

Cloned(Commentary)

Cloned (Comment)	Organism
into a baculoviral vector for expression in Sf-21 cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C299S/C526S	mutant, relative activity: 70%	Homo sapiens
F59C	mutant, relative activity: 50%	Homo sapiens
F66C	mutant, relative activity: 50%	Homo sapiens
F84C	mutant, relative activity: 50%	Homo sapiens
G83C	mutant, relative activity: 35%	Homo sapiens
H75C	mutant, relative activity: 70%	Homo sapiens
I63C	mutant, relative activity: 70%	Homo sapiens
I77C	mutant, relative activity: 60%	Homo sapiens
K64C	mutant, relative activity: 70%	Homo sapiens
L60C	mutant, relative activity: 70%	Homo sapiens
L65C	mutant, relative activity: 70%	Homo sapiens
L67C	mutant, relative activity: 40%	Homo sapiens
L78C	mutant, relative activity: 30%	Homo sapiens
N72C	mutant, relative activity: 60%	Homo sapiens
N86C	mutant, relative activity: 50%	Homo sapiens
N89C	mutant, relative activity: 30%	Homo sapiens
N90C	mutant, relative activity: 20%	Homo sapiens
R62C	mutant, relative activity: 50%	Homo sapiens
T61C	mutant, relative activity: 60%	Homo sapiens
T73C	mutant, relative activity: 40%	Homo sapiens
V74C	mutant, relative activity: 60%	Homo sapiens
V87C	mutant, relative activity: 30%	Homo sapiens
V88C	mutant, relative activity: 30%	Homo sapiens
W85C	mutant, relative activity: 10%	Homo sapiens
Y76C	mutant, relative activity: 70%	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Homo sapiens	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
arachidonate + AH2 + O2	Homo sapiens	-	prostaglandin H2 + A + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
using nickel affinity chromatography	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonate + AH2 + O2	-	Homo sapiens	prostaglandin H2 + A + H2O	-	?

Synonyms

Synonyms	Comment	Organism
COX-2	-	Homo sapiens
cyclooxygenase-2	-	Homo sapiens
PGHS-2	-	Homo sapiens
prostaglandin endoperoxide H2 synthase-2	-	Homo sapiens

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Release 2023.1 (January 2023)