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Literature summary for 1.14.99.38 extracted from
- Krueppel-like factor 4 regulation of cholesterol-25-hydroxylase and liver X receptor mitigates atherosclerosis susceptibility (2017), Circulation, 136, 1315-1330 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesterol + AH2 + O2 | Mus musculus | - |
25-hydroxycholesterol + A + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9Z0F5 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endothelial cell | - |
Mus musculus | - |
| macrophage | - |
Mus musculus | - |
| monocyte | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesterol + AH2 + O2 | - |
Mus musculus | 25-hydroxycholesterol + A + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CH25H | - |
Mus musculus |
| cholesterol-25-hydroxylase | - |
Mus musculus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | vasoprotective stimuli such as pulsatile shear stress and statins increase the expression of the enzyme via Krueppel-like factor 4 | up |
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Release 2023.1 (January 2023)
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