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Literature summary for 1.14.99.39 extracted from

  • Keener, W.K.; Russell, S.A.; Arp, D.J.
    Kinetic characterization of the inactivation of ammonia monooxygenase in Nitrosomonas europaea by alkyne, aniline and cyclopropane derivatives (1998), Biochim. Biophys. Acta, 1388, 373-385.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
1,2-dimethylcyclopropane 22 mM, 93% inhibition, mechanism-based inactivator, ammonia enhances the rate of inactivation Nitrosomonas europaea
1,3-phenylenediamine 0.05 mM, 93% inhibition, mechanism-based inactivator, ammonia enhances the rate of inactivation Nitrosomonas europaea
1-hexyne mechanism-based inactivator, ammonia enhances the rate of inactivation Nitrosomonas europaea
3-Aminophenol 0.25 mM, 39% inhibition Nitrosomonas europaea
3-hexyne mechanism-based inactivator, ammonia enhances the rate of inactivation Nitrosomonas europaea
4-chloroaniline 0.25 mM, 20% inhibition Nitrosomonas europaea
Acetylene mechanism-based inactivator, ammonia slows the rate of inactivation Nitrosomonas europaea
aniline 0.25 mM, 29% inhibition Nitrosomonas europaea
anisole 0.25 mM, 33% inhibition Nitrosomonas europaea
cyclopropyl bromide 0.007 mM, 97% inhibition, mechanism-based inactivator, ammonia slows the rate of inactivation Nitrosomonas europaea
cyclopropylamine 2.5 mM, 22% inhibition Nitrosomonas europaea
additional information no inhibition by 0.6 mM cyclopropane Nitrosomonas europaea
p-anisidine 0.05 mM, 98% inhibition, mechanism-based inactivator, ammonia enhances the rate of inactivation Nitrosomonas europaea
resorcinol 0.25 mM, 27% inhibition Nitrosomonas europaea

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.85
-
 ammonia pH 7.8, 30°C Nitrosomonas europaea

Organism

Organism UniProt Comment Textmining
Nitrosomonas europaea
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ammonia + AH2 + O2
-
 Nitrosomonas europaea NH2OH + A + H2O
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.097
-
 cyclopropyl bromide pH 7.8, 30°C Nitrosomonas europaea
1
-
 p-anisidine pH 7.8, 30°C Nitrosomonas europaea