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Literature summary for 1.14.99.66 extracted from

  • Hu, X.; Li, X.; Valverde, K.; Fu, X.; Noguchi, C.; Qiu, Y.; Huang, S.
    LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis (2009), Proc. Natl. Acad. Sci. USA, 106, 10141-10146.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.99.66

Protein Variants

Protein Variants Comment Organism
additional information shRNA-mediated knockdown of LSD1 in murine erythroleukemia cells cells resulted in derepression of the TAL1 target gene accompanied by increasing dimeH3K4 at the promoter region Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information TAL1-associated LSD1, HDAC1, and their enzymatic activities are coordinately down-regulated during the early phases of erythroid differentiation Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme is organized in histone demethylase complexes containing LSD1, RE1 silencing transcription factor corepressor, CoREST, histone deacetylase 1, HDAC1, and histone deacetylase 2 in erythroleukemia and T cell leukemia cells. the Complex interacts with TAL, a critical transcription factor required for hematopoiesis, overview. The enzymatic domain of LSD1 plays an important role in repressing the TAL1-directed transcription, overview. TAL1-associated LSD1 and HDM activity are dynamically regulated during hematopoiesis ?
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 Mus musculus
-
 [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
LSD1 in the histone demethylase complex also containing CoREST, HDAC1, and HDAC2 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
erythroleukemia cell
-
 Mus musculus
-
T-lymphoblastic leukemia cell line
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is organized in histone demethylase complexes containing LSD1, RE1 silencing transcription factor corepressor, CoREST, histone deacetylase 1, HDAC1, and histone deacetylase 2 in erythroleukemia and T cell leukemia cells. the Complex interacts with TAL, a critical transcription factor required for hematopoiesis, overview. The enzymatic domain of LSD1 plays an important role in repressing the TAL1-directed transcription, overview. TAL1-associated LSD1 and HDM activity are dynamically regulated during hematopoiesis Mus musculus ?
-
 ?
[histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2
-
 Mus musculus [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?

Synonyms

Synonyms Comment Organism
LSD1
-
 Mus musculus
lysinespecific demethylase 1
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus TAL1-associated LSD1, HDAC1, and their enzymatic activities are coordinately down-regulated during the early phases of erythroid differentiation down

General Information

General Information Comment Organism
physiological function the enzymatic domain of LSD1 plays an important role in repressing the TAL1-directed transcription. TAL1 recruits LSD1 to the silenced p4.2 promoter in undifferentiated, but not in differentiated, murine erythroleukemia cells. LSD1 negatively regulates TAL1-mediated transcription and suggest that the dynamic regulation of TAL1-associated LSD1/HDAC1 complex determines the onset of erythroid differentiation programs Mus musculus