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Literature summary for 1.14.99.66 extracted from

  • Liu, L.; Souto, J.; Liao, W.; Jiang, Y.; Li, Y.; Nishinakamura, R.; Huang, S.; Rosengart, T.; Yang, V.; Schuster, M.; Ma, Y.; Yang, J.
    Histone demethylase LSD1 is involved in SALL4 mediated transcriptional repression in hematopoietic stem cells (2013), J. Biol. Chem., 288, 34719-34728.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
coexpression of HA-tagged SALL4 and FLAG-tagged LSD1 in HEK-293 cells, coexpression of LSD1 and SALL4 proteins in mouse bone marrow hematopoietic stem and progenitor cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information hairpin RNA enzyme LSD1 knockdown, RNAi rescue experiments by expressing the human LSD1 cDNA Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 Mus musculus
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histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
?
histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 Mus musculus C57/BL6J
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histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57/BL6J
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
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Mus musculus
-
hematopoietic stem cell
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Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
Mus musculus histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
?
histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2
-
Mus musculus C57/BL6J histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
-
?

Synonyms

Synonyms Comment Organism
histone demethylase
-
Mus musculus
LSD1
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Mus musculus

General Information

General Information Comment Organism
malfunction Cre-induced deletion of SALL4 in gene-targeted BM progenitors results in a remarkable decrease of SALL4-bound and LSD1-bound EBF1, accompanied by a 750fold increase of Lys4-dimethylated histon H3. Knockdown of LSD1 in bone marrow hematopoietic stem and progenitor cells leads to altered SALL4 downstream gene expression and increased cellular activity Mus musculus
physiological function histone demethylase LSD1 is involved in SALL4 mediated transcriptional repression in hematopoietic stem cells, SALL4 and LSD1 co-occupy the same regions of GATA1, CEBPA, and TNF promoters, and SALL4 does dynamically recruit LSD1 to its target genes. LSD1 also appears to act as a central regulator for hematopoietic stem and progenitor cell proliferation and differentiation Mus musculus