General Stability | Organism |
---|---|
the enzyme is remarkably stable at high temperatures and even under denaturing conditions | Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | the concentration of enzyme bound Cu2+ is 1.63 mg/l, the enzyme catalyzes the disproportionation of superoxide via its Cu ion redox cycle [Cu-(II)/Cu(I)], replacement of natural cofactor Cu2+ by isotopically enriched 65Cu, method, overview | Bos taurus | |
additional information | quantitative determination of an isotopically enriched metalloenzyme containing two different metal isotopes, method development, overview | Bos taurus | |
Zn2+ | the concentration of enzyme bound Zn2+ is 1.68 mg/l, the Zn ion plays a structural role, replacement of natural cofactor Zn2+ by isotopically enriched 68Zn, method, overview | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Bos taurus | SOD inhibits the autoxidation of pyrogallol | ? | - |
? | |
O2.- + H+ | Bos taurus | the enzyme catalyzes the disproportionation of superoxide via its Cu ion redox cycle [Cu-(II)/Cu(I)], protecting the organism from oxidative stress, while the neighboring Zn ion plays a structural role | O2 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Bos taurus | - |
additional information | quantitative determination of an isotopically enriched metalloenzyme containing two different metal isotopes, method development, overview | Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activities of the native metalloenzyme and isotopically enriched metalloenzyme containing two different metal isotopes, measurement of SOD inhibition of the autoxidation of pyrogallol, method development, overview | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | SOD inhibits the autoxidation of pyrogallol | Bos taurus | ? | - |
? | |
O2.- + H+ | - |
Bos taurus | O2 + H2O2 | - |
? | |
O2.- + H+ | the enzyme catalyzes the disproportionation of superoxide via its Cu ion redox cycle [Cu-(II)/Cu(I)], protecting the organism from oxidative stress, while the neighboring Zn ion plays a structural role | Bos taurus | O2 + H2O2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
Cu/Zn-SOD | - |
Bos taurus |
SOD | - |
Bos taurus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
additional information | - |
the enzyme is remarkably stable at high temperatures | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.2 | - |
assay at | Bos taurus |