Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dihydrotestosterone | - |
Rattus norvegicus | |
estradiol | - |
Rattus norvegicus | |
Melatonin | - |
Rattus norvegicus | |
additional information | activation of intermembrane space SOD1 upon oxidation of critical thiols. Melatonin, testosterone, dihydrotestosterone, estradiol, and vitamin D induce activation of SOD1 in mitochondria. Enzyme activation is not affected by furafylline, a selective inhibitor of the P450 1A2 isoform, but is inhibited by omeprazole and ketoconazole | Rattus norvegicus | |
testosterone | - |
Rattus norvegicus | |
vitamin D | - |
Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amiodarone | - |
Rattus norvegicus | |
amitriptyline | - |
Rattus norvegicus | |
ketoconazole | - |
Rattus norvegicus | |
Mg2+ | - |
Rattus norvegicus | |
additional information | melatonin, testosterone, dihydrotestosterone, estradiol, and vitamin D induce activation of SOD1 in mitochondria. Enzyme activation is not affected by furafylline, a selective inhibitor of the P450 1A2 isoform, but is inhibited by omeprazole and ketoconazole, and by tiron, a superoxide radical specific scavenger | Rattus norvegicus | |
Omeprazole | - |
Rattus norvegicus | |
Tiron | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial intermembrane space | - |
Rattus norvegicus | 5758 | - |
additional information | subcellular localization study of SOD1, overview | Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | a CuZn-superoxide dismutase | Rattus norvegicus | |
Zn2+ | a CuZn-superoxide dismutase | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male rats | - |
Rattus norvegicus Wistar | - |
male rats | - |
Purification (Comment) | Organism |
---|---|
native enzyme from mitochondrial intermembrane space of livber microsomes | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
Cu,Zn-superoxide dismutase | - |
Rattus norvegicus |
SOD1 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | expression and activity of the mitochondrial P450 system along with substrate availability may contribute to mitochondrial function regulation via activation of IMS SOD1. Activation of intermembrane space SOD1 after incubation of rat liver intact mitochondria with P450 substrates significantly prevents the loss of aconitase activity in the mitochondrial matrix, general mechanism for the SOD1 activation mediated by P450 enzymes, overview | Rattus norvegicus |