Cloned (Comment) | Organism |
---|---|
gene sodC, DNA and amino acid sequence determination and analysis, recombinant expression of His-tagged enzyme in Escherichia coli, recombinant overexpression of the enzyme from AS454(pREB102) in an Escherichia coli sodC mutant leads to complementation restoring resistance to H2O2 killing to wild-type levels | Coxiella burnetii |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diethyldithiocarbamate | a specific inhibitor for CuZn-SODs | Coxiella burnetii | |
H2O2 | inhibition at 5 mM | Coxiella burnetii |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Coxiella burnetii | - |
- |
periplasm | - |
Coxiella burnetii | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | a CuZn-superoxide dismutase | Coxiella burnetii | |
Zn2+ | a CuZn-superoxide dismutase | Coxiella burnetii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 superoxide + 2 H+ | Coxiella burnetii | - |
O2 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Coxiella burnetii | Q83AQ8 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant His-tagged enzyme from Escherichia coli | Coxiella burnetii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 superoxide + 2 H+ | - |
Coxiella burnetii | O2 + H2O2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 18000, recombinant His-tagged enzyme, SDS-PAGE | Coxiella burnetii |
Synonyms | Comment | Organism |
---|---|---|
copper-zinc superoxide dismutase | - |
Coxiella burnetii |
Cu/Zn superoxide dismutase | - |
Coxiella burnetii |
Cu/ZnSOD | - |
Coxiella burnetii |
SOD | - |
Coxiella burnetii |
SodC | - |
Coxiella burnetii |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 9 | active at | Coxiella burnetii |
General Information | Comment | Organism |
---|---|---|
physiological function | the ZnSOD is a potentially important virulence factor | Coxiella burnetii |