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Literature summary for 1.15.1.1 extracted from
- Cloning, expression, and characterization of a Coxiella burnetii Cu/Zn superoxide dismutase (2015), BMC Microbiol., 15, 99 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene sodC, DNA and amino acid sequence determination and analysis, recombinant expression of His-tagged enzyme in Escherichia coli, recombinant overexpression of the enzyme from AS454(pREB102) in an Escherichia coli sodC mutant leads to complementation restoring resistance to H2O2 killing to wild-type levels | Coxiella burnetii |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diethyldithiocarbamate | a specific inhibitor for CuZn-SODs | Coxiella burnetii |  |
| H2O2 | inhibition at 5 mM | Coxiella burnetii | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | the enzyme is secreted | Coxiella burnetii | - |
- |
| periplasm | - |
Coxiella burnetii | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | a CuZn-superoxide dismutase | Coxiella burnetii | |
| Zn2+ | a CuZn-superoxide dismutase | Coxiella burnetii | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 superoxide + 2 H+ | Coxiella burnetii | - |
O2 + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Coxiella burnetii | Q83AQ8 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant His-tagged enzyme from Escherichia coli | Coxiella burnetii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 superoxide + 2 H+ | - |
Coxiella burnetii | O2 + H2O2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 18000, recombinant His-tagged enzyme, SDS-PAGE | Coxiella burnetii |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| copper-zinc superoxide dismutase | - |
Coxiella burnetii |
| Cu/Zn superoxide dismutase | - |
Coxiella burnetii |
| Cu/ZnSOD | - |
Coxiella burnetii |
| SOD | - |
Coxiella burnetii |
| SodC | - |
Coxiella burnetii |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 9 | active at | Coxiella burnetii |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the ZnSOD is a potentially important virulence factor | Coxiella burnetii |
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