Activating Compound | Comment | Organism | Structure |
---|---|---|---|
CIPK23 | a protein kinase, required for enzyme activity because CIPK23 helps in iron aquisition. Involvement of calcium-dependent CBL-CIPK23 complexes in the regulation of iron acquisition | Arabidopsis thaliana |
Cloned (Comment) | Organism |
---|---|
gene FRO2, quantitative real-time PCR isozyme expression analysis | Arabidopsis thaliana |
gene FRO3, quantitative real-time PCR isozyme expression analysis | Arabidopsis thaliana |
gene FRO5, quantitative real-time PCR isozyme expression analysis | Arabidopsis thaliana |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 Fe(II)-siderophore + NAD(P)+ + H+ | Arabidopsis thaliana | - |
2 Fe(III)-siderophore + NAD(P)H | - |
? | |
2 Fe(II)-siderophore + NAD(P)+ + H+ | Arabidopsis thaliana Col-0 | - |
2 Fe(III)-siderophore + NAD(P)H | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | F4I4K7 | - |
- |
Arabidopsis thaliana | P92949 | - |
- |
Arabidopsis thaliana | Q9FLW2 | - |
- |
Arabidopsis thaliana Col-0 | F4I4K7 | - |
- |
Arabidopsis thaliana Col-0 | P92949 | - |
- |
Arabidopsis thaliana Col-0 | Q9FLW2 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 Fe(II)-ferrozine + NAD(P)+ + H+ | - |
Arabidopsis thaliana | 2 Fe(III)-ferrozine + NAD(P)H | - |
? | |
2 Fe(II)-ferrozine + NAD(P)+ + H+ | - |
Arabidopsis thaliana Col-0 | 2 Fe(III)-ferrozine + NAD(P)H | - |
? | |
2 Fe(II)-siderophore + NAD(P)+ + H+ | - |
Arabidopsis thaliana | 2 Fe(III)-siderophore + NAD(P)H | - |
? | |
2 Fe(II)-siderophore + NAD(P)+ + H+ | - |
Arabidopsis thaliana Col-0 | 2 Fe(III)-siderophore + NAD(P)H | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FCR | - |
Arabidopsis thaliana |
ferric chelate reductase | - |
Arabidopsis thaliana |
FRO protein | - |
Arabidopsis thaliana |
FRO2 | - |
Arabidopsis thaliana |
FRO3 | - |
Arabidopsis thaliana |
FRO5 | - |
Arabidopsis thaliana |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5 | - |
assay at | Arabidopsis thaliana |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Arabidopsis thaliana | |
NADPH | - |
Arabidopsis thaliana |
Organism | Comment | Expression |
---|---|---|
Arabidopsis thaliana | lesion of CIPK23 renders Arabidopsis mutants hypersensitive to iron deficiency by downregulating ferric chelate reductase activity | down |
General Information | Comment | Organism |
---|---|---|
malfunction | lesion of CIPK23 renders Arabidopsis mutants hypersensitive to iron deficiency by downregulating ferric chelate reductase activity, leading to chlorosis in young leaves and lower iron concentration than wild-type plants under iron-deficient conditions, phenotype, overview | Arabidopsis thaliana |
metabolism | the protein kinase CIPK23 is involved in iron acquisition. Lesion of CIPK23 renders Arabidopsis mutants hypersensitive to iron deficiency, as evidenced by stronger chlorosis in young leaves and lower iron concentration than wild-type plants under iron-deficient conditions by downregulating ferric chelate reductase activity. Iron deficiency evokes an increase in cytosolic Ca2+ concentration, and the elevated Ca2+ binds to CBL1/CBL9, leading to activation of CIPK23, CBL-CIPK23complexes might be as nutritional sensors to sense and regulate the mineral homeostasis in Arabisopsis thaliana. Regulation of FCR activity by CIPK23 may not be achieved by modulation of genes FRO2, FRO3 and FRO5 at transcriptional level | Arabidopsis thaliana |
physiological function | FCR activity in plants not only depends on FRO expression, abundance of FRO proteins, and but also depends on the levels of heme, ATP and NADPH/NADH | Arabidopsis thaliana |