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Literature summary for 1.16.3.1 extracted from

  • Honarmand Ebrahimi, K.; Hagedoorn, P.L.; Hagen, W.R.
    Inhibition and stimulation of formation of the ferroxidase center and the iron core in Pyrococcus furiosus ferritin (2010), J. Biol. Inorg. Chem., 15, 1243-1253.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.16.3.1

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information steady-state kinetics of iron mineralization and of Fe(II) oxidation and thermodynamics, overview Pyrococcus furiosus

Metals/Ions

Metals/Ions Comment Organism Structure
additional information also other oxoanions, besides phosphate and vanadate, increase the oxidation rate of iron Pyrococcus furiosus
phosphate phosphate does not affect the oxidation rate of the first 48 Fe(II) per ferritin aerobically added to apoferritin. But, it does increase the iron-oxidation rate of subsequent additions of 48 Fe(II) per ferritin by a factor of 6. Phosphate increases the oxidation rate of iron Pyrococcus furiosus
vanadate increases the oxidation rate of iron Pyrococcus furiosus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4 Fe2+ + 4 H+ + O2 Pyrococcus furiosus
-
 4 Fe3+ + 2 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Pyrococcus furiosus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4 Fe2+ + 4 H+ + O2
-
 Pyrococcus furiosus 4 Fe3+ + 2 H2O
-
 ?
additional information competitive binding with Zn2+ Pyrococcus furiosus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22 25 assay at Pyrococcus furiosus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Pyrococcus furiosus

General Information

General Information Comment Organism
additional information structure of the diiron binding site of ferritin, overview Pyrococcus furiosus
physiological function ferritin is a ubiquitous iron-storage protein that has 24 subunits. Each subunit of ferritins that exhibit high Fe2+ oxidation rates has a diiron binding site, the socalled ferroxidase center. The role of the ferroxidase center appears to be essential for the iron-oxidation catalysis of ferritins Pyrococcus furiosus