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Literature summary for 1.17.1.11 extracted from

  • Wang, S.; Huang, H.; Kahnt, J.; Thauer, R.K.
    Clostridium acidurici electron-bifurcating formate dehydrogenase (2013), Appl. Environ. Microbiol., 79, 6176-6179.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.17.1.11

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Gottschalkia acidurici 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
18400
-
 x * 99000 (formate dehydrogenase subunit FdhF2) + x * 68000 (HylB) + x * 35900 (HylA) + x * 18400 (HylC), SDS-PAGE, calculated from sequence Gottschalkia acidurici
35900
-
 x * 99000 (formate dehydrogenase subunit FdhF2) + x * 68000 (HylB) + x * 35900 (HylA) + x * 18400 (HylC), SDS-PAGE, calculated from sequence Gottschalkia acidurici
68000
-
 x * 99000 (formate dehydrogenase subunit FdhF2) + x * 68000 (HylB) + x * 35900 (HylA) + x * 18400 (HylC), SDS-PAGE, calculated from sequence Gottschalkia acidurici
99000
-
 x * 99000 (formate dehydrogenase subunit FdhF2) + x * 68000 (HylB) + x * 35900 (HylA) + x * 18400 (HylC), SDS-PAGE, calculated from sequence Gottschalkia acidurici

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
formate + 2 NAD+ + 2 oxidized ferredoxin iron-sulfur cluster Gottschalkia acidurici
-
 CO2 + 2 NADH + 2 reduced ferredoxin iron-sulfur cluster
-
 ?
formate + 2 NAD+ + 2 oxidized ferredoxin iron-sulfur cluster Gottschalkia acidurici DSM 604
-
 CO2 + 2 NADH + 2 reduced ferredoxin iron-sulfur cluster
-
 ?

Organism

Organism UniProt Comment Textmining
Gottschalkia acidurici K0B3A3 and K0AXR5 and K0B622 and K0B468 K0B3A3: formate dehydrogenase subunit, K0AXR5: subunit HylA, K0B622: subunit HylB, K0B468: subunit HylC
-
Gottschalkia acidurici DSM 604 K0B3A3 and K0AXR5 and K0B622 and K0B468 K0B3A3: formate dehydrogenase subunit, K0AXR5: subunit HylA, K0B622: subunit HylB, K0B468: subunit HylC
-

Purification (Commentary)

Purification (Comment) Organism
-
 Gottschalkia acidurici

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
formate + 2 NAD+ + 2 oxidized ferredoxin iron-sulfur cluster
-
 Gottschalkia acidurici CO2 + 2 NADH + 2 reduced ferredoxin iron-sulfur cluster
-
 ?
formate + 2 NAD+ + 2 oxidized ferredoxin iron-sulfur cluster ferredoxin is not reduced in the absence of NAD+, and NAD+ is not reduced in the absence of ferredoxin. NADP+ can not substitute for NAD+ Gottschalkia acidurici CO2 + 2 NADH + 2 reduced ferredoxin iron-sulfur cluster
-
 ?
formate + 2 NAD+ + 2 oxidized ferredoxin iron-sulfur cluster
-
 Gottschalkia acidurici DSM 604 CO2 + 2 NADH + 2 reduced ferredoxin iron-sulfur cluster
-
 ?
formate + 2 NAD+ + 2 oxidized ferredoxin iron-sulfur cluster ferredoxin is not reduced in the absence of NAD+, and NAD+ is not reduced in the absence of ferredoxin. NADP+ can not substitute for NAD+ Gottschalkia acidurici DSM 604 CO2 + 2 NADH + 2 reduced ferredoxin iron-sulfur cluster
-
 ?

Subunits

Subunits Comment Organism
? x * 99000 (formate dehydrogenase subunit FdhF2) + x * 68000 (HylB) + x * 35900 (HylA) + x * 18400 (HylC), SDS-PAGE, calculated from sequence Gottschalkia acidurici

Synonyms

Synonyms Comment Organism
electron-bifurcating formate dehydrogenase
-
 Gottschalkia acidurici
Fdh/Hyl
-
 Gottschalkia acidurici

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Gottschalkia acidurici

Cofactor

Cofactor Comment Organism Structure
Fe-S center the enzyme contains iron-sulfur clusters Gottschalkia acidurici
FMN enzyme preparation contains FMN Gottschalkia acidurici
NAD+ NADP+ can not substitute for NAD+ Gottschalkia acidurici