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Literature summary for 1.17.1.9 extracted from
- Formate dehydrogenase - a biocatalyst with novel applications in organic chemistry (2011), Org. Biomol. Chem., 9, 7941-7950.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-hydroxybutyl acetate | IC50 of 15.6 vol% | [Candida] boidinii |  |
| ethanol | IC50 of 4.8 vol% | [Candida] boidinii | |
| Isopropanol | IC50 of 4.7 vol% | [Candida] boidinii | |
| methanol | IC50 of 10.2 vol% | [Candida] boidinii | |
| n-butanol | IC50 of 1.4 vol% | [Candida] boidinii | |
| n-Propanol | IC50 of 2.5 vol% | [Candida] boidinii | |
| phenol | IC50 of 0.32 vol% | [Candida] boidinii | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.7 | - |
phenyl formate | in 100 mM potassium phosphate buffer at pH 7.5, at 30°C | [Candida] boidinii | |
| 2.9 | - |
methyl formate | in 100 mM potassium phosphate buffer at pH 7.5, at 30°C | [Candida] boidinii | |
| 4.1 | - |
ethyl formate | in 100 mM potassium phosphate buffer at pH 7.5, at 30°C | [Candida] boidinii | |
| 4.4 | - |
formate | in 100 mM potassium phosphate buffer at pH 7.5, at 30°C | [Candida] boidinii | |
| 4.7 | - |
propyl formate | in 100 mM potassium phosphate buffer at pH 7.5, at 30°C | [Candida] boidinii | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| formate + NAD+ | [Candida] boidinii | - |
CO2 + NADH + H+ | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| [Candida] boidinii | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-(formyloxy)butyl acetate + NAD+ | 59% conversion | [Candida] boidinii | ? | - |
? | |
| butyl formate + NAD+ | 41% conversion | [Candida] boidinii | ? | - |
? | |
| ethyl formate + NAD+ | 26% conversion | [Candida] boidinii | ? | - |
? | |
| formate + NAD+ | - |
[Candida] boidinii | CO2 + NADH + H+ | - |
ir | |
| methyl formate + NAD+ | 23% conversion | [Candida] boidinii | ? | - |
? | |
| phenyl formate + NAD+ | 86% conversion | [Candida] boidinii | ? | - |
? | |
| propyl formate + NAD+ | 39% conversion | [Candida] boidinii | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FDH | - |
[Candida] boidinii |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
[Candida] boidinii | |
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Release 2023.1 (January 2023)
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